Analysis of cognitive function and its influenced factors in patients with prostate cancer after maximal androgen blockade therapy
Bibliographic record
Abstract
Objective To investigate the cognitive function of patients with prostate cancer after maximal androgen blockade therapy and its influenced factors, and to provide a new way for early prevention strategy. Methods Montreal cognitive assessment (MoCA), hospital anxiety depression scale (HAD), social support rating scale (SSRS) and self-designed questionnaire were used in 56 cases treated with maximum androgen blockade therapy for more than six months and 37 cases who underwent radical prostatectomy treatment to evaluate their cognitive function and collect the observation indexes between January 2013 and October 2015. Based on MoCA score, all patients were divided into cognitive dysfunction group (n=40) and normal cognitive function group (n=53). The observation indexes in two groups were compared and cognitive function with different treatment in two groups were analyzed. The changes on the influencing factors of cognitive function in patients were filtered using multivariable logistic regression analysis. Results In the cognitive dysfunction group and normal group, the proportion of MAB treatment was 80.0% (32/40) vs. 45.3% (24/53), the age was 73.7 vs. 73.7 years, the proportion of solitary was 32.5% (13/40) vs. 13.2% (7/53), the proportion of depressive symptoms was 87.5% (35/40) vs. 62.3% (33/53), the social support level was 32.5 vs. 41.1 and the proportion of testosterone decreased was 95.0% (38/40) vs. 45.3% (24/53). All events showed statistically significant differences (P<0.05). Compared MAB treatment group with radical surgical treatment group, the testosterone level was (0.27±0.15) vs. (12.14±1.86) nmol/L, visual space and executive function score was 4.18±0.79 vs. 4.54±0.56, attention score was 4.73±0.99 vs. 5.16±0.79, delayed memory score was 3.75±1.21 vs. 4.30±1.05 and MoCA score was 26.13±1.48 vs. 27.27±1.39, which all showed the statistically significant difference (P<0.05). The results of multiple regression analysis showed that age (OR=1.183, 95%CI 1.135-1.223), depressive symptoms (OR=1.092, 95%CI 1.047-1.149), social support (OR=0.897, 95%CI 0.838-0.956), testosterone (OR=2.105, 95%CI 1.369-4.083) were the influenced factors of cognitive dysfunction. Conclusions The incidence of cognitive dysfunction in patients with prostate cancer after maximal androgen blockade therapy more than six months was higher than others. Age, depression, social support level and testosterone levels were related to the occurrence of cognitive dysfunction. Key words: Prostate cancer; Maximal androgen blockade; Cognitive function
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".