Association between blood glucose control and mild cognitive impairment in patients with diabetes mellitus and small-artery occlusion
Bibliographic record
Abstract
Objective To study the association between blood glucose control and mild cognitive impairment (MCI) in patients with diabetes mellitus and small-artery occlusion (SAO). Methods A screening study of cognitive impairment was conducted in the 676 patients diagnosed with SAO who had been treated at Department of Neurology, Huanhu Hospital from January 2010 through June 2017. They were divided into a normal cognition group (n=629) and an MCI group (n=47) according to the screening results. They were also divided into 4 groups according to their history of diabetes and levels of hemoglobin A1c: normal blood glucose group (n=398), stringent goals group (n=59), general goals group (n=46) and goals-not-met group (n=173). The differences were compared in terms of Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MoCA) scores between the normal blood glucose, stringent goals, general goals and goals-not-met groups. We also analyzed the general clinical data and risk factors between the normal cognition and MCI groups. Variables of confounders that were identified as significant were entered into logistic regression. Results There were significant differences in MMSE and MoCA scores between the 4 groups (P<0.05). Between the normal cognition and MCI groups, significant differences were found in proportion of smokers, blood glucose level and severity of stroke (P<0.05). Logistic regression analysis showed that compared with the normal blood glucose group the incidence of MCI was 2.707-fold higher in the stringent goals group (OR=2.707, 95% CI: 1.035~7.083, P=0.042), 2.963-fold higher in the general goals group (OR=2.963, 95% CI: 1.064~8.277, P=0.038) and 2.604-fold higher in the goals-not-met group (OR=2.604, 95% CI: 1.269~5.341, P=0.009). Conclusions MCI is more likely to occur in acute phase in patients with diabetes and SAO stroke. The patients can benefit from joint managements of diabetes, stroke and cognitive dysfunction in clinical practice. Key words: Stroke; Small-artery occlusion; Diabetes mellitus; Blood glucose control; Mild cognitive impairment
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".