Clinical predictive factors of deep remission in Crohn′s disease treated with anti-tumor necrosis factor α
Bibliographic record
Abstract
Objective To investigate the predictors of deep remission in patients with Crohn′s disease (CD) treated with infliximab. Methods From February 2008 to February 2015, the clinical, laboratory and follow up data of 44 CD patients who received infliximab treatment and maintained clinical remission over six months were retrospectively analyzed. Mucosal healing was defined as no ulcer under endoscopy. Deep remission was defined as clinical remission with mucosal healing. According to results of endoscopy examination, the enrolled patients were divided into deep remission group and non-deep remission group.T test or Wilcoxon rank sum test was used for comparison of measurement data between groups, and chi square test was performed for the rate comparison. Multivariate analysis was made with Logistic regression. Results Median age of 44 patients was 19.5 yeares, 39 males (88.6%), five females (11.4%), and the median disease duration was 35.0 months (18.5 to 73.5 months). Deep remission was achieved in 20 CD patients with long-time follow-up (median follow-up time 19 months, 12 to 29 months). The mean duration of achieving deep remission was (28.9±14.3) weeks.There was no statistically significant difference between 20 patients with deep remission and 24 patients without deep remission in age of onset, disease duration, smoking status, Montreal phenotype, concurrent medications (mesalazine, steroids and azathioprine), as well as body mass index (BMI) and laboratory tests (erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hsCRP), hemoglobin (Hb) and platelet (PLT) count) before administrating. The results of Logistic regression demonstrated that extraintestinal manifestations (arthralgia) (odds ratio (OR)=29.9, 95% confidence interval (CI) 1.26-714.20, P=0.036), normalization of hs CRP at 14th week after induced remission (OR=0.88, 95%CI 0.78-0.99, P=0.045) and thrombocytopenia (OR=0.98, 95%CI 0.96-0.99, P=0.016) were independent predictive factors of deep remission. Conclusions Infliximab could effectively maintain long term deep remission in treatment of CD. Arthralgia, normalization of hsCRP and PLT counts at 14th week after induced remission are predictive factor of deep remission. Key words: Crohn′s disease; Infliximab; Mucosal healing; Deep remission
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".