Effect of dexmedetomidine on myocardial injury marker and postoperative recognition during cardiac surgery
Bibliographic record
Abstract
Objective To observe the effect of dexmedetomidine (DEX) on myocardial injury marker and postoperative recognition during cardiac surgery. Methods Fifty patients diagnosed with rheumatic heart disease were randomly divided into experiment group and control group. The experiment group was treated by DEX, and the control group was treated by normal saline. The removal time, intensive care unit (ICU) retention time, resuscitation after opening aortic, vital signs, changes of myocardial injury markers, and incidence of postoperative recognition were compared. Results There was no significant difference in the removal time, ICU retention time, and resuscitation after opening aortic between the two groups (P>0.05). The levels of systolic blood pressure (SBP) in the experiment group [(97.26±11.18), (106.93±11.75), and (104.35±11.09) mmHg (1 mmHg=0.133 kPa)] were higher than in the control group [(83.17±10.69), (95.16±13.33), and (97.03±7.08) mmHg] from period of cardiopulmonary bypass to the end of surgery (P<0.05); The levels of diastolic blood pressure (DBP) in the experiment group [(70.06±11.43), (60.44±9.47), (61.40±8.66), and (63.63±7.61) mmHg] after injection of loading dose, longitudinal sternotomy, the period from cardiopulmonary bypass to the end of surgery were higher than in the control group [(57.22±12.43), (56.45±9.06), (55.23±6.59), and (56.62±6.88) mmHg, P<0.05]; The levels of heart rate (HR) in the experiment group [(66.37±9.59), and (68.62±10.08)/min] after the incision, and longitudinal sternotomy were lower than in the control group [(75.52±12.08), and (81.64±8.79)/min, P<0.05]. The levels of 24-h human heart fatty acid binding protein (H-FABP) in the experiment group [(0.49±0.09), (1.74±0.13), (1.97±0.11), and (1.41±0.13) μg/ml] were lower than those in the control group [(0.58±0.14), (1.97±0.26), (2.35±0.41), and (1.57±0.21) μg/ml] after completion of cardiopulmonary bypass to the end of surgery (P<0.05); The levels of 24-h Creatine kinase isoenzyme MB(CK-MB) in the experiment group [(89.69±15.88) U/ml] were lower than in the control group [(116.85±18.27) U/ml, P<0.05]; The levels of 24-h cardiac Troponin Ⅰ (cTnⅠ) in the experiment group [(1.43±0.18), and (1.20±0.21) ng/ml] were lower than in the control group [(1.79±0.21), and (1.47±0.14) ng/ml, P<0.05]; The scores of mini-mental state examination (MMSE) and Montreal cognitive assessment scale (MoCA) in the experiment group [(28.23±1.52)/min, and (24.25±1.35)/min] were higher than those in the control group [(26.22±1.43)/min, and (22.03±1.51)/min, P<0.05]. Conclusion It can be concluded that DEX may reduce the myocardial injury and improve the condition of postoperative recognition. It could better maintain the hemodynamic stability during cardiac surgery. Key words: Cardiac surgery; Dexmedetomidine; Myocardial injury marker; Cognitive function
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".