Study on the correlation between cerebral hemodynamics and cognitive function in patients with chronic obstructive pulmonary disease
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Bibliographic record
Abstract
Objective To evaluate the characteristics of cerebral hemodynamics and its correlation with cognitive function in patients with chronic obstructive pulmonary disease (COPD). Methods Two hundred outpatients with COPD and 200 sex-and age-matched outpatients over the same period were used as a control group.Monteal Cognitive Assessment (MoCA) were used to evaluate the cognitive function.The mean flow velocity (Vm), pulsatility index (PI), resistance index (RI) and breath holding index (BHI) of bilateral middle cerebral artery (MCA) were examined by means of transcranial Doppler ultrasound in all subjects. Results The score of COPD group significantly was lower than that in control group [(22.95±3.71) scores vs (26.12±0.90) scores], the frequency of MoCA≤25 group was 21.5% in COPD group, significantly higher than that in control group (9.0%). Compared with control group, Vm [(53.31±0.96) cm/s vs (46.80±0.83) cm/s], BHI(1.21±0.72 vs 0.72±0.12) significantly decreased, and PI (0.83±0.04 vs 1.14±0.59), RI(0.52±0.04 vs 0.66±0.41) significantly increased in MoCA≤25 COPD group.Compared with MoCA>25 COPD group, BHI (0.98±0.91 vs 0.72±0.12) of MoCA≤25 COPD group significantly decreased, and PI (1.10±0.41 vs 1.14±0.59), RI (0.55±0.79 vs 0.66±0.41) significantly increased. Conclusions Cognitive function and cerebral hemodynamics in patients with COPD are impaired.PI has a positive correlation with the likelihood of cognitive impairment, howere, BHI has the opposite relationship. Key words: Chronic obstructive pulmonary disease; Hemodynamics; Cognition impariment; Transcranial Doppler
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it