Correlation between serum homocysteine level and mild cognitive impairment in patients with Parkinson's disease
Bibliographic record
Abstract
Objective To investigate the correlation between mild cognitive impairment (PD-MCI) and serum homocysteine (Hcy) in patients with Parkinson's disease. Methods 85 patients with PD (43 with PD-MCI, 42 with PDN) as the observation group and 43 healthy elderly patients as the control group.The demographic information, clinical and neuropsychological assessments were conducted and the Hcy of fasting venous blood were detected in all subjects.The Hcy level and its associated factors were also analyzed in the PD group. Results Serum levels of Hcy in the PD patients((13.53±2.29) μmol/L) were higher than those in the HC group((11.77±1.56) μmol/L) , the difference was statistically significant (t=4.57, P<0.05). There was significant difference in serum Hcy levels among HC group, PDN group((12.85±1.88)μmol/L) and PD-MCI group((14.22±2.47)μmol/L) (F=16.13, P<0.01). Hcy level of the PDN group was higher than that of the HC group (P<0.05), and PD-MCI group was higher than PDN group (P<0.05). Serum levels of Hcy in patients with PD-MCI were significantly associated with UPDRS-Ⅲ(r=0.305), H-Y(r=0.313), LEDD(r=0.424), MMSE(r=-0.470), MoCA(r=-0.503), duration of connection test B(r=0.617) and semantic fluency tests(r=0.557)(all P<0.05). Conclusion Elevated serum Hcy levels are expected to be biomarkers for predicting PD-MCI. Key words: Parkinson's disease; Mild cognitive impairment; Homocysteine level in serum
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".