Effects of hyperbaric oxygen on the cognition of the patients with stroke during the acute stage of cerebral infarction
Bibliographic record
Abstract
Objective To investigate the effects of hyperbaric oxygen (HBO) on the cognition of the patients with stroke during the acute stage of cerebral infarction. Methods Ninety-four patients with acute cerebral infarction hospitalized in the department of the hospital from January to March, 2017 were enrolled for the study. A randomized controlled study was performed and the patients were randomly divided into 2 groups. During hospitalization, the treatment group was treated with HBO in addition to conventional treatment for cerebral infarction, while the control group was just given conventional therapy for cerebral infarction. National Institutes of Health Stroke Scale (NIHSS) scores and MoCA scores were assessed at time of admission. After 6 months of follow-ups, 4 patients with recurrent cerebral infarction or death or without medical follow-ups were excluded from the study, and the remaining 90 were included in the study. NIHSS scores, MoCA scores and mRS scores were calculated once again for the study. General medical data and scores were compared between the groups. Logistic regression was used to identify independent influential factors of cognitive impairment after stroke. Results There was no statistical significance in general medical data and various scores detected at the time of admission, when comparisons were made between the 2 groups. Six months after onset, statistical significance could neither be seen in NIHSS scores and the rate of good outcome, as compared with those of the control group. However, incidence of cognitive impairment after stroke was significantly lower than that of the control group(26.7% vs 48.9%)(P<0.05). Six months after onset, the MoCA scores were significantly lower than those of the control group, with statistical significance (27.3±1.52 vs 26.2±1.95) (P<0.05). Six months after onset of cerebral infarction, the scores of visual space/executive function and memory in the HBO group were considerably higher than those in the control group [4(4, 5)vs 4(4, 4)] (P<0.05). Logistic regression analysis revealed that education background (OR=0.711, 95% CI 0.556-0.910) (P=0.007), homocysteine (OR=1.271, 95% CI 1.015-1.591)(P=0.037) and leukoaraiosis (OR=2.854, 95% CI 1.327-6.147) (P=0.007) were independent factors of cognitive impairment after stroke, and whether not to choose HBO therapy was not an independent factor of cognitive impairment after stroke. Conclusion HBO therapy during the acute stage of cerebral infarction seemed to have little effect on the prognosis of the impairment 6 months after onset. However, it could significantly reduce the incidence of cognitive impairment after stroke and improve the visual spatial/executive function and memory. Key words: Hyperbaric oxygen; Stroke; Cognition
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".