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Record W3033287571 · doi:10.1016/j.jcf.2020.05.011

Building global development strategies for cf therapeutics during a transitional cftr modulator era

2020· review· en· W3033287571 on OpenAlexafffund
Nicole Mayer-Hamblett, Silke van Koningsbruggen‐Rietschel, David P. Nichols, Donald R. VanDevanter, Jane C. Davies, T. Lee, Anthony G. Durmowicz, Félix Ratjen, Michael W. Konstan, Kelsie Pearson, Scott C. Bell, John Clancy, Jennifer L. Taylor‐Cousar, K. De Boeck, Scott H. Donaldson, D.G. Downey, Patrick A. Flume, Pavel Dřevı́nek, Christopher H. Goss, Isabelle Fajac, Amalia Magaret, Bradley S. Quon, Sabrina Singleton, Jill M. VanDalfsen, George Retsch‐Bogart

Bibliographic record

VenueJournal of Cystic Fibrosis · 2020
Typereview
Languageen
FieldMedicine
TopicCystic Fibrosis Research Advances
Canadian institutionsUniversity of British ColumbiaUniversity of Toronto
FundersNational Center for Advancing Translational SciencesNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteMedical Research CouncilSouth Carolina Clinical and Translational Research Institute, Medical University of South CarolinaNational Institutes of HealthQueen's UniversityNational Health and Medical Research CouncilQueen's University BelfastEuropean CommissionGilead SciencesCystic Fibrosis CanadaChildren's Hospital FoundationNational Institute for Health and Care ResearchMedical University of South CarolinaU.S. Food and Drug AdministrationUniversity of South CarolinaChiesi FarmaceuticiNovartisMichael Smith Health Research BCCystic Fibrosis Foundation
KeywordsMedicineHarmonizationDrug developmentCystic fibrosisGlobeProcess (computing)Intensive care medicinePharmacologyComputer scienceDrugInternal medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.954
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.048
GPT teacher head0.380
Teacher spread0.332 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations31
Published2020
Admission routes2
Has abstractno

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