The antispasmodic effect of aqueous root bark extract of Carissa edulis (Forssk.) Vahl on isolated rabbit jejunum is mediated through blockade of calcium channels
Bibliographic record
Abstract
BackgroundSpasms of the gut underlie hyperactive gut disorders. These conditions are highly prevalent and impart greater health care cost. Herbal antispasmodic remedies form a source of affordable, safe and easily available treatments in low resource areas. There is, therefore, a need to scientifically evaluate the therapeutic potential of these remedies. This study investigated the antispasmodic effect of aqueous root bark extract of Carissa edulis, herb used to manage hyperactive gut disorders such as abdominal colic and diarrhea.Materials and methodsPieces of jejunum were isolated from adult New Zealand White rabbits. They were mounted in an organ bath containing Tyrode’s solution. The rate and force of contraction were recorded using Powerlab coupled to Chart5 Software. The effects of the extract (0.1-10.0 mg/ml) on spontaneous jejunal contraction were investigated. The effect of 1.0 and 3.0 mg/ml extract was investigated on acetylcholine, KCl and CaCl2 induced contraction.ResultsCarissa edulis extract dose-dependently (0.1-10 mg/ml) significantly decreased the force but not the rate of spontaneous jejunal contraction. Extract (1 and 3 mg/) significantly decreased the magnitude of acetylcholine, KCl and CaCl2 induced contraction.Conclusions Aqueous root bark extracts of Carissa edulis possess a significant antispasmodic effect on rabbit jejunum. This appears to be through calcium channel blockade. These results validate its use as a remedy for hyperactive gut disorders.Â
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".