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Record W3036749792 · doi:10.1016/j.annonc.2020.06.006

HSD3B1 (1245A>C) germline variant and clinical outcomes in metastatic castration-resistant prostate cancer patients treated with abiraterone and enzalutamide: results from two prospective studies

2020· article· en· W3036749792 on OpenAlexafffund
Daniel Khalaf, Isabel M. Aragón, Matti Annala, Rosa M. Lozano, Sinja Taavitsainen, David Lorente, Daygen L. Finch, Nuria Romero-Laorden, Joanna Vergidis, Ylenia Cendón, Conrad D. Oja, M.I. Pacheco, Maria Zulfiqar, Elena Almagro, José Ángel Arranz, Pablo Borrega, Elena Castro, J.A. Cuello Contreras, Marta Doménech, Ricardo Sánchez-Escribano, E. Fernández-Parra, Enrique Gallardo, I. García-Carbonero, R. García, J. Garde, Aranzazu González del Alba, Belén González Sánchez, Amaia Hernández, Susana Hernando, Pablo Gálvez Jiménez, Núria Laínez, E. Martínez García, Ana Medina, María José Méndez-Vidal, A. Montesa, Rafael Morales, José Luis Perez‐Gracia, Begoña Pérez‐Valderrama, Ana Catarina Pinto, Josep M. Piulats, Javier Puente, Rosa Querol, Alejo Rodríguez‐Vida, M.I. Sáez, Erik Velez, José Carlos Villa-Guzmán, R. Villatoro, C. Zambrana, Martin Gleave, Alexander W. Wyatt, David Olmos, K.N. Chi

Bibliographic record

VenueAnnals of Oncology · 2020
Typearticle
Languageen
FieldMedicine
TopicProstate Cancer Treatment and Research
Canadian institutionsAbbotsford Veterinary ClinicSurrey Memorial HospitalUniversity of British Columbia, Okanagan CampusKelowna General HospitalUniversity of British Columbia
FundersCanadian Cancer Society Research InstituteGenentechBC Cancer FoundationCilagAstellas PharmaMinisterio de Ciencia e InnovaciónInstituto de Salud Carlos IIIProstate Cancer CanadaIpsenClovis OncologyCelgeneBC Cancer AgencyProstate Cancer FoundationMovember FoundationBristol-Myers SquibbAstraZenecaPfizerSanofiJane ja Aatos Erkon Säätiö
KeywordsEnzalutamideMedicineProstate cancerHazard ratioOncologyInternal medicineProportional hazards modelGenotypeAndrogen deprivation therapyConfidence intervalCancerAndrogen receptorBiologyGenetics

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.016
Threshold uncertainty score0.529

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.170
GPT teacher head0.469
Teacher spread0.299 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations44
Published2020
Admission routes2
Has abstractno

Explore more

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