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Record W3037234117 · doi:10.3390/cancers12061672

Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe

2020· review· en· W3037234117 on OpenAlexaff
Giulia Veronesi, David Baldwin, Claudia I. Henschke, Simone Ghislandi, Sergio Iavicoli, Matthijs Oudkerk, Harry J. de Koning, Joseph Shemesh, John K. Field, Javier J. Zulueta, Denis Horgan, Lucia Fiestas Navarrete, Maurizio Infante, Pierluigi Novellis, Rachael L Murray, Nir Peled, Cristiano Rampinelli, Gaetano Rocco, Witold Rzyman, Giorgio V. Scagliotti, Martin C. Tammemägi, Luca Bertolaccini, Natthaya Triphuridet, Rowena Yip, Alexia Rossi, Suresh Senan, Giuseppe Ferrante, Kate Brain, Carlijn van der Aalst, Lorenzo Bonomo, Dario Consonni, Jan P. van Meerbeeck, Patrick Maisonneuve, Silvia Novello, Anand Devaraj, Zaigham Saghir, Giuseppe Pelosi

Bibliographic record

VenueCancers · 2020
Typereview
Languageen
FieldMedicine
TopicLung Cancer Diagnosis and Treatment
Canadian institutionsBrock University
FundersIstituto Nazionale per l'Assicurazione Contro Gli Infortuni sul LavoroNational Cancer InstituteAssociazione Italiana per la Ricerca sul CancroMinistero della Salute
KeywordsComputed tomographyLung cancerLung cancer screeningMedicineRadiologyMedical physicsTomographyNuclear medicineOncology

Abstract

fetched live from OpenAlex

Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39-61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the "Initiative for European Lung Screening (IELS)"-a large international group of physicians and other experts concerned with lung cancer-agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.960
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.063
GPT teacher head0.387
Teacher spread0.325 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designOther design
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations88
Published2020
Admission routes1
Has abstractyes

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