PP.20.28
Bibliographic record
Abstract
Objective: We have previously shown that there is a blood pressure independent reduction in aortic stiffness as early as 3 months after successful a kidney transplantation (KTx). The purpose of the present study is to examine the effects of KTx on changes in aortic stiffness after 2 years of follow-up. Design and method: In this prospective, longitudinal observational study, we studied hemodynamic and biological parameters prior to KTx and 3, 6 and 24 months after a KTx in 59 dialysis patients. Aortic stiffness was measured by carotid-femoral pulse wave velocity (cf-PWV). A successful kidney transplant was defined by an estimated eGFR of 45 or more mL/min/1.732 at the time of the measurement of aortic stiffness. A GEE model was used to take into account the repeated measures of aortic stiffness and mean blood pressure. Values are reported as mean ± SEM unless otherwise specified. Results: The mean age was 48 ± 14 years, with 70% male, 20% with cardiovascular disease and 25% diabetes. After adjusting for mean blood pressure, cf-PWV decreased significantly from 11.2 ± 0.33 to 10.3 ± 0.30 by 3 months (P = 0.042), but it increased to 10.8 ± 0.31 and 11.2 ± 0.33 (m/s) by 6 and 24 months (P = NS versus preKTx). The rate of progression of aortic stiffness beyond 3 months was 0.248 m/s/year.Conclusions: After an initial improvement of aortic stiffness, there is a progression of aortic stiffness that is numerically lower than what has been previously been reported in dialysis population.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".