Study of Anticancer Activity of Pratensein and Pratensein Glycoside Isolated from Cuscuta kotchiana
Why this work is in the frame
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Bibliographic record
Abstract
In the present paper, we demonstrate that extract of Cuscuta kotchiana is able to inhibit in vitro proliferation of two human breast cancer cell lines, MCF-7 and MDA-MB-231. The expression levels of p53, bcl-2, caspase-3 and bax genes at the mRNA and protein levels were evaluated using quantitative Real Time PCR and western blot analysis. The most active fractions of C. kotchiana were detected by NMR as pratensein and pratensein glycoside. The cytotoxic activity of pratensein glycoside was significantly more than pratensein. The expression level of bcl2 gene was decreased in cancer cells treated by both compounds at CC50 concentrations. But the expression levels of caspase-3, p53 and bax genes were increased in treated cancer cells. In conclusion, all the data demonstrated that the glycoside form of pratensein is important agent in inducing apoptosis in human breast cancer cells.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it