046 Feasibility, Acceptability and Effects of Physical Therapy Treatment for Gynecological Cancer Survivors with Dyspareunia
Bibliographic record
Abstract
Dyspareunia affects more than half of gynecological cancer survivors. These women are confronted with this serious health issue as well as relationship difficulties and psychological distress. Despite the impact on their quality of life, the available treatments remain limited and poorly studied. Physical therapy (PT) has been shown to be highly effective to treat dyspareunia in younger populations with no history of cancer. However, no study has investigated PT in gynecological cancer survivors with dyspareunia. The main goal of this single-arm pilot study was to evaluate the feasibility and acceptability of a 12-week PT treatment in gynecological cancer survivors with dyspareunia. Secondary goals included examining the effects of PT in terms of frequency of sexual activities, pain quality and intensity, sexual function, sexual distress as well as patient’s satisfaction and global impression of change. Women who had completed treatment for a gynecological malignancy for at least 3 months, and were considered cured, were eligible to participate if they reported vulvovaginal pain at an intensity of ≥5 on a numerical rating scale (NRS: 0-10), for at least 80% of sexual intercourse attempts, for more than 3 months. The treating gynecologic oncologist performed a standardized pelvic and rectal examination to confirm eligibility. PT treatment consisted of 12 weekly 60-minute individual sessions including education, pelvic floor muscle exercises with biofeedback, manual therapy and home exercises. Attendance rate (proportion of sessions attended) and adherence rate (proportion of completed home exercises according to a diary) were calculated to describe feasibility and acceptability, as primary outcomes. Secondary outcomes concerning treatment effects were collected at baseline and post-treatment by a physical therapist not involved in patient’s care. They included frequency of sexual activities with vaginal penetration (number per month), pain quality (McGill Pain Questionnaire; minimal clinically important difference (MCID) -30%) and intensity (NRS; MCID -2), sexual function (Female Sexual Function Index; MCID +2.1) and sexual distress (Female Sexual Distress Scale-Revised; MCID -7). Level of satisfaction with treatment (NRS: 0-10) and Patient Global Impression of Change (PGIC 7-point scale: very much improved to very much worse) were also used. Paired t-tests or Wilcoxon signed-rank tests were conducted in conformity to data distribution to investigate the changes from baseline to post-treatment.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.014 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".