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Record W3040782867 · doi:10.1038/s41375-020-0979-6

Spliceosome mutations are common in persons with myeloproliferative neoplasm-associated myelofibrosis with RBC-transfusion-dependence and correlate with response to pomalidomide

2020· letter· en· W3040782867 on OpenAlexaff
Onima Chowdhury, Jennifer O’Sullivan, Nikolaos Barkas, Guanlin Wang, Gemma Buck, Angela Hamblin, Ayalew Tefferi, Haifa Kathrin Al‐Ali, Giovanni Barosi, Timothy Devos, Heinz Gisslinger, Qian Jiang, Jean‐Jacques Kiladjian, Ruben A. Mesa, Francesco Passamonti, Vincent Ribrag, Gary J. Schiller, Alessandro M. Vannucchi, Daobin Zhou, Mary Frances McMullin, Robert Peter Gale, Adam J. Mead, John Catalano, William Stevenson, Günther Gastl, Werner Linkesch, Jan Van Droogenbroeck, Philippe Mineur, Vikas Gupta, Andrew R. Turner, Thomas J. Nevill, Jianyong Li, Zhixiang Shen, Ting Liu, Dominique Bordessoule, Shanti Natarajan‐Amé, Christian Récher, Jean Loup Demory, Richard F. Schlenk, Martin Grießhammer, Mario Cazzola, Giuseppe Saglio, Giorgina Specchia, Alessandro Rambaldi, Fabrizio Pane, Sonja Zweegman, Peter A.W. te Boekhorst, Reinier Raymakers, Abdulkadyrov Km, М А Соколова, Galina Salogub, Andrey Zaritskiy, Francisco Cervantes, Juan Carlos Hernández‐Boluda, Emilio Ojeda, Daniel Tesfa, Lars Nilsson, Mark W. Drummond, John T. Reilly, Claire Harrison, Dragana Milojković, Candido E. Rivera, Emmanuel C. Besa, H. Joachim Deeg, John Mascarenhas, Josef T. Prchal, Ramón V. Tiu, Moshe Talpaz, Jen C. Wang, Raajit K. Rampal, Damiano Rondelli, Kelly McCaul, Randall W. Brown, Norio Komatsu, Kazuma Ohyashiki, Kiyoshi Ando, Hiroshi Kawabata, Katsuto Takenaka, Tomoko Hata, James W. Vardiman

Bibliographic record

VenueLeukemia · 2020
Typeletter
Languageen
FieldMedicine
TopicMyeloproliferative Neoplasms: Diagnosis and Treatment
Canadian institutionsVancouver General HospitalOntario Institute for Cancer ResearchPrincess Margaret Cancer Centre
FundersRosetrees TrustNational Cancer InstituteMedical Research CouncilNational Institute for Health and Care ResearchCancer Research UK
KeywordsPomalidomideMyelofibrosisMyeloproliferative neoplasmMedicinePolycythemia veraHematologySpliceosomeNeoplasmMyeloproliferative DisordersInternal medicinePathologyBone marrowBiologyGeneticsMultiple myelomaGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.148
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.003
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.238
Teacher spread0.226 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations9
Published2020
Admission routes1
Has abstractno

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