Oscillometry to Assess Respiratory Function in Adult Cystic Fibrosis
Bibliographic record
Abstract
Oscillometry to Assess Respiratory Function in Adult Cystic Fibrosis Background and Rationale: Cystic fibrosis (CF) is a life-limiting multi-system disorder in which respiratory dysfunction predominates. Although spirometry is the most commonly used test of pulmonary function, it has recognized limitations. Oscillometry is an alternative test of respiratory function which provides complementary information. Oscillometry also offers a number of practical and physiological advantages and is increasingly used in both clinical research and patient care. Surprisingly, little data exists using oscillometry to evaluate lung function in adults with CF. Accordingly, the aim of this study was to compare spirometry and oscillometry in a large adult CF cohort. Methods: Spirometry and oscillometry (tremoFlo® C-100, Thorasys Thoracic Medical Systems Inc., Montreal, Canada) were performed according to published guidelines during a routine visit to the Montreal Chest Institute Adult CF Clinic, McGill University Health Centre in 92 adults with established CF in stable state (mean age = 33.0 ± SE 1.3 yrs, 51 men). Oscillometry parameters included respiratory resistance at 5 Hz (R5), the difference in respiratory resistance at 5 and 20 Hz (R5-20), respiratory reactance at 5 Hz (X5), respiratory reactance area (AX), and resonant frequency (Fres). Results: Respiratory function was significantly reduced for the group (forced expiratory volume in one second, FEV1 = 2.27 ± SE 0.1 L; Z score = -3.38 ± SE 0.23). There was generally a good to strong correlation between spirometry and oscillometry parameters, particularly between FEV1 and both X5 and AX, and all relationships were highly significant (P < 0.001). Results were generally similar when expressed as absolute values or Z scores. Logistic regression and marginal models estimated via general estimating equations analyses between spirometry and oscillometry parameters showed a significant association between oscillometry parameters (i.e., R5, R5-20, X5, and AX) and abnormal spirometry parameters. Conclusions: Oscillometry appears to be a reliable measure of impaired respiratory function in stable adult CF. Further work is needed to assess its ability to reliably identify changes in function occurring either spontaneously or with therapeutic interventions, particularly in comparison with spirometry, patient reported outcomes, and other measures
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".