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Record W3042076923 · doi:10.1016/j.molcel.2020.06.029

Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling

2020· article· en· W3042076923 on OpenAlexafffund
Callie P. Wigington, Jagoree Roy, Nikhil P. Damle, Vikash Kumar Yadav, Cecilia Blikstad, Eduard Resch, Cassandra J. Wong, Douglas R. Mackay, Jennifer T. Wang, Izabella Krystkowiak, Devin A. Bradburn, Eirini Tsekitsidou, Su Hyun Hong, Malika Amyn Kaderali, Shou‐Ling Xu, Tim Stearns, Anne‐Claude Gingras, Katharine S. Ullman, Ylva Ivarsson, Norman E. Davey, Martha Cyert

Bibliographic record

VenueMolecular Cell · 2020
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicSignaling Pathways in Disease
Canadian institutionsLunenfeld-Tanenbaum Research InstituteUniversity of TorontoMount Sinai Hospital
FundersNational Institute of General Medical SciencesCarl Tryggers Stiftelse för Vetenskaplig ForskningOntario GenomicsNational Institutes of HealthVetenskapsrådetScience Foundation IrelandGovernment of CanadaCanadian Institutes of Health ResearchLOEWE-Zentrum für Translationale Medizin und PharmakologieOntario Research FoundationGovernment of OntarioStanford University
KeywordsBiologyIn silicoPhosphataseCalcineurinCell biologyInteractomeProteomeComputational biologyNuclear transportAnkyrin repeatBiochemistryPhosphorylationGeneCell nucleus

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0010.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.237
Teacher spread0.224 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations85
Published2020
Admission routes2
Has abstractno

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