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Record W3044498899

Falsified antimicrobial medicine: A neglected global health crisis contributing to drug resistance

2019· article· en· W3044498899 on OpenAlexaff
Erin Slade

Bibliographic record

VenueGlobal Health: Annual Review · 2019
Typearticle
Languageen
FieldMedicine
TopicPharmaceutical Quality and Counterfeiting
Canadian institutionsMcMaster University
Fundersnot available
KeywordsMalariaPublic healthMedicineInfectious disease (medical specialty)AntimicrobialGlobal healthAntibiotic resistanceEnvironmental healthDrug resistanceDrugDiseaseIntensive care medicinePharmacologyBiologyAntibioticsImmunologyPathology
DOInot available

Abstract

fetched live from OpenAlex

Falsified antimicrobial drugs pose a significant challenge for global public health. Falsified drugs are those that have been intentionally compromised in terms of quality – they may contain too little, wrong or no active ingredient, or may be mislabeled and contain other toxic substances. An estimated 10-30% of medicine globally is falsified, where Sub-Saharan Africa and Southeast Asia are flooded with poor quality antimalarial, antituberculosis and antiretroviral medications. Falsified treatment for these diseases has dangerous implications for health in countries struggling amidst high burdens of infectious disease, under-funded health systems and political instability. This opinion editorial will examine the consequences of falsified antimicrobial medication for malaria, TB and HIV, and will argue that tackling false medicines is a missing piece of the puzzle towards eradicating drug resistance.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.344
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0000.002
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.448
Teacher spread0.416 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2019
Admission routes1
Has abstractyes

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