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Record W3045371551 · doi:10.1101/2020.07.20.20157552

A comparison of therapies using Eyetronix Flicker Glass And standard adhesive patches in children with anisometropic amblyopia: A randomized controlled trial

2020· preprint· en· W3045371551 on OpenAlexaff
Seung Hyun Min, Shijia Chen, Jinling Xu, Bingzhen Chen, Hui Chen, Yuwen Wang, Jiawei Zhou, X. D. Yu

Bibliographic record

VenuemedRxiv · 2020
Typepreprint
Languageen
FieldMedicine
TopicOphthalmology and Visual Impairment Studies
Canadian institutionsMcGill University
FundersNational Natural Science Foundation of ChinaWenzhou UniversityWenzhou Medical University
KeywordsMedicineRandomized controlled trialVisual acuityOphthalmologyFlicker fusion thresholdContrast (vision)FlickerSurgeryOptics

Abstract

fetched live from OpenAlex

A bstract Objective Eyetronix Flicker Glass (EFG) has been introduced an alternative treatment for amblyopia. It is based on the premise that amblyopia can better be treated by manipulating the visual input that enter both the normal and amblyopic eye. In contrast, only the normal eye gets deprived during the traditional patching therapy. We conducted a randomized clinical trial to compare the efficacy of the therapies using the Eyetronix Flicker Glass and standard adhesive patches in children with anisometropic amblyopia. Design A prospective, randomized controlled trial Participants: 31 children aged 4-13 years with anisometropic amblyopia Intervention: The patients were assigned two treatment groups and were treated for 12 weeks. Those in the first group were treated with the Eyetronix Flicker Glass for one hour per day, whereas those in the latter group were treated with the standard patches for two hours per day. Main outcome measures Best-corrected visual acuity and contrast sensitivity of the amblyopic eye, stereopsis and fusion range were measured at both before the treatment and 3, 6 and 12 weeks after the first day of the treatment. Results Visual acuity of the amblyopic eye significantly improved in both groups after the treatment (p < 0.05), albeit more so in patients who had undergone the standard patching therapy. A significant improvement in contrast sensitivity of the amblyopic eye at 3, 6 and 12 cpd was also observed in patients who had undergone the standard patching therapy (p < 0.05) but not the EFG therapy (p > 0.05). However, no improvement in stereopsis and fusion range was found in patients from both treatment groups. Conclusion Both therapies improved monocular visual functions, such as visual acuity and contrast sensitivity. However, the improvement was significantly larger after the standard patching therapy than that of the EFG therapy. However, both therapies did not improve fusion range and stereopsis. Our results indicate that although the EFG therapy deprives visual input in a binocular fashion, it does not improve binocular functions in the amblyopic population.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.025

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.005
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0060.004
Bibliometrics0.0010.001
Science and technology studies0.0010.002
Scholarly communication0.0020.002
Open science0.0020.001
Research integrity0.0040.003
Insufficient payload (model declined to judge)0.0070.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.048
GPT teacher head0.377
Teacher spread0.328 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2020
Admission routes1
Has abstractyes

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