Editorial: The Role of Heat Shock Proteins in Neuroprotection
Bibliographic record
Abstract
This Research Topic covers an increasingly important topic on the "Role of Heat Shock Proteins in Neuroprotection".With a growing elderly population and an ever-increasing amount of resources required to treat neurodegeneration, there is a growing demand for solutions.Chaperone systems represent the major pro-survival strategy for cells of living organisms in response to stress.Heat shock proteins are associated with neurological disease because they can suppress or promote the aggregation of misfolded toxic proteins.This Research Topic brings together a number of selected articles that show how diverse heat shock proteins impact on neurodegenerative disease.The review by Webster et al. discusses the role that misfolding, aggregation, and aberrant accumulation of proteins play as a central component in the progression of neurodegenerative disease.While molecular chaperones are normally protective, they can also promote the stabilization of toxic protein aggregates, which can lead to neurodegenerative disease.The authors review the role by which sHsps modulate neurodegenerative disease-relevant protein aggregation.The manuscript by Gracia et al. looks at the therapeutic potential of the Hsp90/Cdc37 interaction in neurodegenerative disease, such as Alzheimer's, Huntington's, and Parkinson's.This article presents evidence that client proteins, and in particular kinases, may be differentially affected when modulating the Hsp90/Cdc37 chaperone system, depending on the strength of their interaction with this chaperone complex.Consequently, this may allow therapeutic intervention by targeting Hsp90/ Cdc37-client protein complexes, which are currently underexplored.The role of heat shock protein's in neuroinflammation is discussed by Dukay et al.Apart from the classical molecular chaperoning of heat shock proteins, they are shown to play a role in neurological disorders by modulating neuronal survival, inflammation, and disease-specific signalling processes.Although the processes of neuro-inflammation are not yet fully understood, the authors explore the existing literature on the inflammatory function of heat-shock-proteins within the central nervous system.Cristofani et al. then investigates the role of HSPB8 on the protein quality control system of cells.This system prevents the deleterious effects of misfolded proteins of which HSPB8 is a component.Elevated levels of HSPB8, activated by misfolded proteins through transcription, contribute to preventing the aggregation of misfolded proteins, facilitate autophagy, and enable the efficient clearance of the misfolded proteins.In conclusion, the Research Topic brings together some important topics showing how heat shock proteins are central to many neurological disease processes and how intervention by modulating
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.012 |
| Meta-epidemiology (narrow) | 0.004 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.002 |
| Bibliometrics | 0.003 | 0.001 |
| Science and technology studies | 0.003 | 0.002 |
| Scholarly communication | 0.005 | 0.004 |
| Open science | 0.003 | 0.001 |
| Research integrity | 0.011 | 0.014 |
| Insufficient payload (model declined to judge) | 0.018 | 0.017 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".