More than meets the eye: Longitudinal visual system neurodevelopment in very preterm children and anophthalmia
Bibliographic record
Abstract
Anophthalmia, characterized by the absence of an eye(s), is a rare major birth defect with a relatively unexplored neuroanatomy. Longitudinal comparison of white matter development in an anophthalmic (AC) very preterm (VPT) child with both binocular VPT and full-term (FT) children provides unique insights into early neurodevelopment of the visual system. VPT-born neonates (<32wks gestational age), including the infant with unilateral anophthalmia, underwent neuroimaging every two years from birth until 8 years. DTI images (N = 168) of the optic radiation (OR) and a control track, the posterior limb of the internal capsule (PLIC), were analysed. The diameter of the optic nerves (ON) were analysed using T1-weighted images. Significant group differences in FA and AD were found bilaterally in the OR and PLIC. This extends the literature on altered white matter development in VPT children, being the first longitudinal study showing stable group differences across the 4, 6 and 8 year timepoints. AC showed greater deficits in FA and AD bilaterally, but recovered towards VPT group means from 4 to 8 years-of-age. Complete lack of binocular input would be responsible for these early deficits; compensatory mechanisms may facilitate structural improvement over time. AC's ON exhibited significant atrophy ipsilateral to the anophthalmic eye. Functionally, AC displayed normal visual acuity and form perception, but naso-temporal bias in motion perception. Following these groups and AC longitudinally enabled novel understanding of the joint influence of monocular vision and VPT birth on neurodevelopment.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".