Czech Republic consensus on recommendations to prevent and manage extravasation (paravasation) of cytotoxic drugs
Bibliographic record
Abstract
Extravasation (paravasation) of cytotoxic chemotherapy drugs represents a very important complication in oncology nursing. Prevention and proper care can reduce the risk of extravasation and its consequences. A consensus on chemotherapy extravasation management have been reached within twenty seven oncology and haemato-oncology centres in the Czech Republic. Ensuring reliable, safe venous access, choice of injection site, venous line control, and patient education are integral and very important parts of care. DMSO (99%) is recommended for topical application after extravasation of anthracyclines, mitomycin C and cisplatin. Dry cold should be applied in case of DMSO-treated cisplatin extravasation, anthracyclines, mitomycin C and in extravasations of all other cytotoxic drugs (except for those with recommended dry heat applications). Dry heat is to be applied in cases of extravasation of oxaliplatin, taxanes and vinca-alkaloids. Hyaluronidase applied subcutaneously around the extravasation is recommended in the case of extravasation of taxanes and vinca-alkaloids. Dexrazoxane i.v. can be used when dealing with extravasation of anthracyclines. Corticosteroids applied subcutaneously, moist heat or cooling, are not recommended.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.012 | 0.021 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.005 |
| Bibliometrics | 0.005 | 0.003 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.004 | 0.002 |
| Open science | 0.005 | 0.003 |
| Research integrity | 0.006 | 0.005 |
| Insufficient payload (model declined to judge) | 0.012 | 0.007 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".