Abstract B037: The role of HIV status in health-related quality of life in gay and bisexual prostate cancer survivors: Findings from the Restore study
Bibliographic record
Abstract
Abstract Objective: Prostate cancer is the most common invasive cancer in gay and bisexual men. Despite the unique sexual and urinary concerns of this group, nearly all studies of prostate cancer rehabilitation post-treatment have focused on heterosexual men. Older gay and bisexual men, the generation most likely to experience prostate cancer, also have high prevalence of human immunodeficiency virus (HIV), which is associated with lower quality of life. Research has indicated that people with HIV may experience health disparities in cancer treatment, but to our knowledge, this is the first quantitative study of the association between HIV status and health-related quality of life (HRQOL) in gay and bisexual men with prostate cancer. Methods: Data from the Restore study, a cross-sectional online survey of gay and bisexual men treated for prostate cancer and residing in the United States or Canada, were used to examine this association. The Expanded Prostate Cancer Index Composite (EPIC) was used to assess function and bother in four domains: urinary, sexual, bowel, and hormone. Overall physical and mental HRQOL was assessed utilizing the SF-12 Health Survey. Multivariate analysis of variance (MANOVA) was used to evaluate the association between HIV status and HRQOL scores. Models were adjusted for age, race, treatment (prostatectomy, radiation, or advanced treatment), relationship status (partnered/married versus single/dating/widowed/divorced), preferred role in sex, and number of comorbidities. Results: Of 193 participants, 24 (12.4%) reported an HIV diagnosis, including 3 diagnosed after their prostate cancer treatment. The cohort was 89 percent white, with mean age 63.4 years. After adjustment for demographic and treatment characteristics, HIV-positive status was associated with lower scores on the EPIC urinary (RD: -10.8, 95% CI: -19.5 to -2.2) and sexual (RD: -10.3, 95% CI: -20.2 to -0.4) domains. Although there were no statistically significant associations found in the other domains, HIV-positive participants reported lower outcomes in all domains except the SF-12 mental domain (RD: 0.3, 95% CI: -5.0 to 5.6). Conclusion: Our findings, though imprecise, provide evidence that HIV status may be associated with poorer HRQOL in gay and bisexual prostate cancer survivors. Citation Format: Elizabeth J. Polter, Christopher W. Wheldon, Nidhi Kohli, B. R. S. Rosser. The role of HIV status in health-related quality of life in gay and bisexual prostate cancer survivors: Findings from the Restore study [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr B037.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".