NEONATAL EVOLUTION OF BLOOD PRESSURES IN INFANTS WITH TWIN-TWIN TRANSFUSION SYNDROME
Bibliographic record
Abstract
Background Twin-twin transfusion syndrome (TTTS) carries significant morbidity and mortality. In utero, major volume transfer from the “donor” to the “recipient” is associated in the donor with oliguria and activation of the renin-angiotensin system. The recipient is confronted with an exaggerated volume load and paradoxal high levels of renin and angiotensin. This pathological hemodynamic should lead to high blood pressure (BP) in the recipient. However the immediate neonatal BP of these infants is unknown. Objective Determine the BP in the first 36 hours of life of TTTS infants. Methods Chart review of all TTTS born in our institution between 1996 to 2007 with selection of pairs for which both twins were alive at least 24 hours (56/110 pregnancies). BP values under amine infusion were excluded. Results TTTS were delivered at 30.3 +or- 3.2 weeks of gestation. Cardiac biventricular hypertrophy was only present in recipients (36% vs 0). When expressed relative to predicted BP for the weight (Zubrow et al, 1995), both systolic and diastolic BP were significantly higher in recipients (syst/diast: 122+or-26/111+or-26% vs 84+or-13/75+or-18%). Furthermore, the recipients’ BP diminished over the first 12 h of life contrary to the donor and the normal evolution of BP in neonates. Conclusions Recipients have a significantly high BP and donors a significantly reduced BP for their weight, which supports the hypothesis that recipients are hypertensive in utero. The long-term impact of these early hemodynamic perturbations remains to be determined.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".