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Record W3081411221 · doi:10.7554/elife.60675

Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

2020· article· en· W3081411221 on OpenAlexfundno aff
David W. Eyre, Sheila Lumley, Denise O’Donnell, Mark Campbell, Elizabeth Sims, Elaine Lawson, Fiona C Warren, Tim James, Stuart Cox, Alison Howarth, George Doherty, Stephanie B. Hatch, James Kavanagh, Kevin Chau, Philip W. Fowler, Jeremy Swann, Denis Volk, Fan Yang-Turner, Nicole Stoesser, Philippa C. Matthews, Maria Dudareva, T. J. Davies, R. H. Shaw, Leon Peto, Louise Downs, Alexander Vogt, Ali Amini, Bernadette Young, Philip G. Drennan, Alexander J. Mentzer, Donal Skelly, Fredrik Karpe, Matt J. Neville, Monique Andersson, Andrew Brent, Nicola Jones, Lucas Martins Ferreira, Thomas Christott, Brian D. Marsden, Sarah Hoosdally, Richard J. Cornall, Derrick W. Crook, David I. Stuart, Gavin Screaton, Adam Watson, A Taylor, Alan Chetwynd, Alexander Grassam-Rowe, Alexandra Mighiu, Angus Livingstone, Annabel Killen, Caitlin Rigler, Callum Harries, Cameron East, Charlotte Lee, Chris Mason, Christian Holland, Connor Thompson, Conor Hennesey, Constantinos Savva, David Kim, Edward Harris, Euan J McGivern, Evelyn Qian, Evie Rothwell, Francesca Back, Gabriella Kelly, Gareth Watson, Gregory Howgego, Hannah Chase, Hannah Danbury, Hannah Laurenson-Schafer, Harry Ward, Holly Hendron, Imogen C Vorley, Isabel Tol, James Gunnell, Jocelyn Ward, Jonathan Drake, Joseph D. Wilson, Joshua Morton, Julie Dequaire, Katherine O’Byrne, Kenzo Motohashi, Kirsty Harper, Krupa Ravi, Lancelot Jamie Millar, Liam J Peck, Madeleine Oliver, Marcus Rex English, Mary Kumarendran, Matthew Wedlich, Olivia Ambler, Oscar Deal, Owen Sweeney, Philip Cowie, Rebecca te Water Naudé, Rebecca Young, Rosie Freer, Samuel Scott, Samuel Sussmes, Sarah Peters, Saxon Pattenden, Seren Waite, Síle A. Johnson, Stefan Kourdov, Stephanie Santos-Paulo, Stoyan Dimitrov, Sven Kerneis, Tariq Ahmed-Firani, Thomas B. King, Thomas Ritter, Thomas Foord, Zoe de Toledo, Thomas Christie, Bernadett Gergely, David Axten, Emma-Jane Simons, Heather Nevard, Jane Philips, Justyna Szczurkowska, Kaisha Patel, Kyla Smit, Laura Warren, Lisa Morgan, Lucianne Smith, Maria Robles, Mary McKnight, Michael Luciw, Michelle Gates, Nellia Sande, Rachel Turford, Roshni Ray, Sonam Rughani, Tracey Mitchell, Trisha Bellinger, Vicki Wharton, Anita Justice, Gerald Jesuthasan, Susan Wareing, Nurul Huda Mohamad Fadzillah, Kathryn Cann, Richard Kirton, Claire Sutton, Claudia Salvagno, Gabriella D’Amato, Gemma Pill, Lisa Butcher, Lydia Rylance-Knight, Merline Tabirao, Ruth Moroney, Sarah Wright, Tim Peto, Bruno Holthof, Daniel Ebner, Christopher P. Conlon, Katie Jeffery, A Sarah Walker

Bibliographic record

VenueeLife · 2020
Typearticle
Languageen
FieldMedicine
TopicSARS-CoV-2 and COVID-19 Research
Canadian institutionsnot available
FundersStructural Genomics ConsortiumNational Institute for Health and Care ResearchKennedy Trust for Rheumatology ResearchGovernment of the United KingdomRobertson FoundationWellcome TrustMedical Research FoundationMedical Research CouncilWellcome
KeywordsMedicinePersonal protective equipmentOdds ratioCoronavirus disease 2019 (COVID-19)Observational studySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Intensive care unitOutbreakAsymptomaticHealth careEmergency medicineFamily medicineInternal medicineVirologyInfectious disease (medical specialty)Disease

Abstract

fetched live from OpenAlex

We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45-6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99-3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07-2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28-0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25-2.21]) and Asian (1.51 [1.28-1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34-3.15]).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.012
Threshold uncertainty score0.025

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.005
Meta-epidemiology (narrow)0.0000.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.360
GPT teacher head0.443
Teacher spread0.083 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations287
Published2020
Admission routes1
Has abstractyes

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