Water-Dispersible, Colloidally Stable, Surface-Functionalizable Uniform Fiberlike Micelles Containing a π-Conjugated Oligo(<i>p</i>-phenylenevinylene) Core of Controlled Length
Bibliographic record
Abstract
π-Conjugated-polymer-based fiberlike nanostructures show promising potential in applications ranging from biomedicine to microelectronic devices as a consequence of their shape and their intrinsic optoelectronic characteristics. However, these structures can be fragile and subject to dissociation at elevated temperatures or in the presence of certain solvents, and they can be difficult to functionalize. To address these problems, we have synthesized a diblock copolymer containing a π-conjugated crystalline oligo(p-phenylene vinylene) (OPV) segment and a poly(3-(triethoxysilyl)propyl methacrylate) (PTESPMA) block (OPV5-b-PTESPMA35, the subscripts represent the (mean) number of repeat units of each block). Uniform fiberlike micelles of controlled length from 50 nm to ∼1.2 μm with an OPV core were obtained by self-seeding in ethanol. The PTESPMA corona was then cross-linked by an in situ siloxane condensation without micelle aggregation or degradation. The integrity and colloidal stability of micelles were preserved in a good solvent for the OPV block, in a THF/ethanol mixture (v/v = 4/1), and also upon heating in ethanol at 80 °C. Amino groups were installed onto the surface of shell-cross-linked micelles via second-step siloxane condensation by employing the Si-OH groups of the shell as anchoring sites. The amino groups can be used for further introduction of desired functionalities, e.g., Rhodamine B. In addition, trimethylammonium groups were incorporated onto the surface of micelles. These cationic groups not only endow the micelles with excellent colloidal stability in water without micelle aggregation and fragmentation but also enable the micelles to bind double-stranded DNA. In this way, they may possibly serve as vectors for gene therapy. This work opens a new avenue toward π-conjugated-polymer-based fiberlike nanostructures with excellent length tunability, mechanical and colloidal stability, and a capacity for surface functionalization.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".