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Record W3082087505 · doi:10.1364/osac.404790

Polarization-enabled spectral-focusing CARS microscopy

2020· article· en· W3082087505 on OpenAlexafffund
R. A. Cole, Aaron D. Slepkov

Bibliographic record

VenueOSA Continuum · 2020
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicSpectroscopy Techniques in Biomedical and Chemical Research
Canadian institutionsTrent University
FundersNatural Sciences and Engineering Research Council of CanadaCanada Research Chairs
KeywordsPolarization (electrochemistry)Raman spectroscopyOpticsRaman scatteringMicroscopyPhysicsSpectral lineCoherent anti-Stokes Raman spectroscopyStokes parametersScatteringChemistry

Abstract

fetched live from OpenAlex

We describe a spectral-focusing-based polarization-resolved coherent anti-Stokes Raman scattering (SFP-CARS) microscopy system developed by making simple and inexpensive modifications to an existing spectral focusing CARS setup. By using the system to study polarization dependent features in the CARS spectrum of benzonitrile, we assess its capabilities and demonstrate its ability to accurately determine Raman depolarization ratios. Ultimately, the detected anti-Stokes signals are more elliptically polarized than expected, hindering a complete suppression of the non-resonant background. Furthermore, the fact that resonant signals polarized in directions similar to that of the non-resonant background are also substantially suppressed when extinguishing the non-resonant background remains a serious limitation. We conclude that non-resonant background suppression using the SFP-CARS system is best suited for studying Raman modes that generate signals polarized in directions far from that of the non-resonant background instead of for obtaining background-free CARS spectra. In all, we find that the SFP-CARS setup is a useful tool for studying polarization dependent features in the CARS spectra of various samples that is worthy of further investigation. This work aims to illuminate several technical aspects of polarization dependent CARS and inform researchers of the benefits and constraints of integrating polarization dependent detection as an add-on to existing CARS microscopy setups.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.290
Teacher spread0.281 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2020
Admission routes2
Has abstractyes

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