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Record W3082980940 · doi:10.1101/2020.08.27.270819

Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics

2020· preprint· en· W3082980940 on OpenAlexaff
Ersin Akıncı, Minsun Cha, Lin Lin, Grace Hui Ting Yeo, Marisa C. Hamilton, Callie J. Donahue, Heysol C. Bermudez-Cabrera, Larissa C. Zanetti, Maggie Chen, Sammy Barkal, Benyapa Khowpinitchai, Nam Chu, Minja Velimirovic, Rikita Jodhani, James D. Fife, Miha Sovrovic, Philip A. Cole, Robert A. Davey, Christopher A. Cassa, Richard I. Sherwood

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2020
Typepreprint
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCRISPR and Genetic Engineering
Canadian institutionsUniversité LavalCentre hospitalier de l'Université LavalCentre hospitalier universitaire de Québec
FundersNederlandse Organisatie voor Wetenschappelijk OnderzoekAgency for Science, Technology and ResearchGraduiertenakademie, Technische Universität DresdenMassachusetts Consortium on Pathogen ReadinessQatar Biomedical Research Institute, Hamad Bin Khalifa UniversityFundação de Amparo à Pesquisa do Estado de São PauloAmerican Heart Association
KeywordsCRISPRCas9TranscriptomeGenome editingCytotoxicityComputational biologyGenomeSubgenomic mRNABiologyGeneticsGeneGene expression

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.259
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.244
Teacher spread0.225 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations32
Published2020
Admission routes1
Has abstractyes

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