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Record W3083906113 · doi:10.1007/s00401-020-02209-8

Germline-driven replication repair-deficient high-grade gliomas exhibit unique hypomethylation patterns

2020· article· en· W3083906113 on OpenAlexaff
Andrew Dodgshun, Kohei Fukuoka, Melissa Edwards, Vanessa Bianchi, Anirban Das, Alexandra Sexton‐Oates, Valérie Larouche, Magimairajan Vanan, Scott Lindhorst, Michal Yalon, Gary Mason, Bruce Crooks, Shlomi Constantini, Maura Massimino, Stefano Chiaravalli, Jagadeesh Ramdas, Warren Mason, Ashraf Shamvil, Roula Farah, An Van Damme, Enrico Opocher, Syed Ahmer Hamid, David S. Ziegler, David Samuel, Kristina A. Cole, Patrick Tomboc, Duncan Stearns, Gregory A. Thomas, Alexander Lossos, Michael Sullivan, Jordan R. Hansford, Alan Mackay, Chris Jones, David Jones, Vijay Ramaswamy, Cynthia Hawkins, Éric Bouffet, Uri Tabori

Bibliographic record

VenueActa Neuropathologica · 2020
Typearticle
Languageen
FieldMedicine
TopicGlioma Diagnosis and Treatment
Canadian institutionsCancerCare ManitobaPrincess Margaret Cancer CentreIzaak Walton Killam Health CentreUniversity of ManitobaSickKids FoundationUniversité LavalHospital for Sick Children
FundersStand Up To CancerBrain Tumour CharityCancer Research UKRoyal Children's Hospital Foundation
KeywordsGermlineReplication (statistics)BiologyGeneticsComputational biologyVirologyGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.611
Threshold uncertainty score0.834

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.045
GPT teacher head0.279
Teacher spread0.234 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations44
Published2020
Admission routes1
Has abstractno

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