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Record W3084796809 · doi:10.1016/j.cct.2020.106151

Fragility of clinical trials across research fields: A synthesis of methodological reviews

2020· review· en· W3084796809 on OpenAlexaff
Matthew Holek, Faris Bdair, Mohammed Khan, Michael Walsh, P.J. Devereaux, Stephen D. Walter, Lehana Thabane, Lawrence Mbuagbaw

Bibliographic record

VenueContemporary Clinical Trials · 2020
Typereview
Languageen
FieldDecision Sciences
TopicMeta-analysis and systematic reviews
Canadian institutionsMcMaster UniversityPopulation Health Research InstituteImpactSt. Joseph’s Healthcare Hamilton
Fundersnot available
KeywordsFragilityMedicineQuartileSample size determinationConfidence intervalMeta-analysisRandomized controlled trialStatisticsInternal medicineMathematics

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.991
metaresearch head score (Gemma)0.997
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Meta-epidemiology (broad), Open science, Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesMetaresearch, Meta-epidemiology (narrow), Meta-epidemiology (broad), Research integrity, Insufficient payload (model declined to judge)
DomainCandidate signal: Methods · Consensus signal: Methods
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.795
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.9910.997
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.2420.115
Bibliometrics0.0010.005
Science and technology studies0.0000.002
Scholarly communication0.0010.000
Open science0.0120.002
Research integrity0.0040.005
Insufficient payload (model declined to judge)0.0120.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.999
GPT teacher head0.861
Teacher spread0.138 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designNot applicable
DomainMethods
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations19
Published2020
Admission routes1
Has abstractno

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