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Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial
Denice S. Feig, Lois Donovan, Bernard Zinman, Johanna Sanchez, Elizabeth Asztalos, Edmond A. Ryan, I. George Fantus, Eileen K. Hutton, Anthony Armson, Lorraine L. Lipscombe, David Simmons, Jon Barrett, Paul J. Karanicolas, Siobhan Tobin, David McIntyre, Simon Yu Tian, George Tomlinson, Kellie E. Murphy, Diane Donat, Shital Gandhi, Barbara Cleave, Vivian Zhou, Effie Viguiliouk, Debbie Fong, Michele Strom, Melissa Deans, Aarthi Kamath, Ariane Godbout, Florence Weber, Michèle Mahone, Bi Lan Wo, Marie‐Josée Bédard, M. Robinson, Sylvie Daigle, Sophie Leblanc, Sora Ludwig, Sherri A. Pockett, Laurie Slater, Carolyn Oldford, Catherine A. Young, Heidi Virtanen, Abhay Lodha, Stephanie Cooper, Jennifer M. Yamamoto, Claire Gougeon, Cheryl Verhesen, Afshan Zahedi, Nashwah Taha, Marci Turner, Madalena Neculau, Cathy Robb, Krystyna Szwiega, Grace Lee, Évelyne Rey, Sophie Perreault, Jillian Coolen, Thomas Ransom, R. Palma Dias, Janet Slaunwhite, Darlene Baxendale, Cora A. Fanning, Ilana Halperin, Veronica Gale, Tina Kader, Heidi Hirsimaki, Hélène Long, Julie Lambert, Annie Castonguay, Steve Chalifoux, Ruth McManus, Margaret Watson, Anne-Marie Powell, Munira Sultana, Vinolia Arthur‐Hayward, Mauricio Marin, Lorraine Cauchi, Leila MacBean, Janine Malcolm, Heather D. Clark, Allan Karovitch, Heather G. Belanger, Josée Champagne, K.-H. Schütt†, Jennifer L. Sloan, Joyce Mitchell, Colette Favreau, Elaine O’Shea, Debbie McGuire, Melin Peng, Dynika St Omer, Julie Lee, Jennifer A. Klinke, Sharon Young, Agnieszka Barts, F.Benjamin Carr, Peter Subrt, David B. Miller, Karen Coles, Sarah E. Capes, Galina Smushkin, R Phillips, C.M. Fergusson, Stacey Lacerte, Robyn L. Houlden, Adriana Breen, Bonnie Stone-Hope, Sarah Kwong, Heather Rylance, Rshmi Khurana, Tammy L. McNab, Shirley Beauchamp, S. John Weisnagel, Martin D'Amours, Christyne Allen, Marie‐Christine Dubé, Valérie-Ève Julien, Camille Lambert, Marie-Claude Bourbonniere, Louise Rheaume, Myriam Bouchard, George Carson, Suzanne Williams, Maria Wolfs, Howard Berger, Alice Cheng, Joel G. Ray, Amir Hanna, Leanne De Souza, Leslie Berndl, S. J. Meltzer, Natasha Garfield, Amira El‐Messidi, L. Bastien, Shari Segal, David Thompson, Kenneth Lim, Jason Kong, Sharon V. Thompson, Christine Orr, Brenda Galway, Minnie Parsons, Krista Rideout, Bernadette Rowe, Joan Crane, Wayne Andrews, Carol Joyce, Jill Newstead-Angel, Judy Brandt, Simona Meier, Josephine Laurie, Helen G. Liley, Jane Fox, Helen L. Barrett, Frances B. Maguire, Marnie Nerdal-Bussell, Wenjun Nie, Carolyn Bergan, Bekki Cavallaro, Anne Tremellen, Anne Cook, David J. Simmons, Rohit Rajagopal, Lisa Vizza, Maureen Mattick, Claudia Bishop, Jodie Nema, Renee Kludas, Mark McLean, Susan Hendon, Allison Sigmund, Vincent Wong, Prem Lata, Hamish Russell, Razita Singh, George Fantus, Keitha McMurray, Helen Murphy, Gail Klein, Simon Tian, Kathryn Mangoff
Bibliographic record
VenueThe Lancet Diabetes & Endocrinology · 2020
Typearticle
Languageen
FieldMedicine
TopicGestational Diabetes Research and Management
Canadian institutionsWomen's College HospitalDalhousie UniversityMcMaster UniversityUniversity of AlbertaAlberta Children's HospitalSunnybrook Health Science CentreSinai Health SystemLunenfeld-Tanenbaum Research InstituteMount Sinai HospitalUniversity of CalgaryUniversity Health NetworkHealth Sciences CentreSunnybrook HospitalUniversity of Toronto
FundersRoche Diabetes CareUniversity of TorontoDepartment of Medicine, University of TorontoNovo NordiskCanadian Institutes of Health ResearchNational Institute for Health and Care ResearchSunnybrook Research InstituteMedtronic
KeywordsMedicineMetforminType 2 diabetesPregnancyPostprandialPlaceboRegimenDiabetes mellitusInsulinInternal medicineObstetricsEndocrinology
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.016
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.002 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.027
GPT teacher head0.290
Teacher spread0.263 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations228
Published2020
Admission routes2
Has abstractno