Autoantibodies against type I IFNs in patients with life-threatening COVID-19
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Abstract
The genetics underlying severe COVID-19 The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens IFN response to prevent damage from pathogen-induced inflammation. Two studies now examine the likelihood that genetics affects the risk of severe coronavirus disease 2019 (COVID-19) through components of this system (see the Perspective by Beck and Aksentijevich). Q. Zhang et al. used a candidate gene approach and identified patients with severe COVID-19 who have mutations in genes involved in the regulation of type I and III IFN immunity. They found enrichment of these genes in patients and conclude that genetics may determine the clinical course of the infection. Bastard et al. identified individuals with high titers of neutralizing autoantibodies against type I IFN-α2 and IFN-ω in about 10% of patients with severe COVID-19 pneumonia. These autoantibodies were not found either in infected people who were asymptomatic or had milder phenotype or in healthy individuals. Together, these studies identify a means by which individuals at highest risk of life-threatening COVID-19 can be identified. Science , this issue p. eabd4570 , p. eabd4585 ; see also p. 404
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The record
- Venue
- Science
- Topic
- SARS-CoV-2 and COVID-19 Research
- Field
- Medicine
- Canadian institutions
- McGill University Health Centre
- Funders
- NHLBI Division of Intramural ResearchInstituto de Salud Carlos IIINational Health and Medical Research CouncilMercatus Center, George Mason UniversityNovo Nordisk FondenUniformed Services University of the Health SciencesAmerican Association for the Advancement of ScienceNational Institutes of HealthNational Center for Advancing Translational SciencesMedical Research CouncilRegione LombardiaFondation pour la Recherche MédicaleEuropean CommissionMinisterio de Ciencia e InnovaciónFondazione TelethonZonMwInstitut National de la Santé et de la Recherche MédicaleU.S. Department of DefenseAgencia Estatal de InvestigaciónUniversity of New South WalesYale UniversityNational Human Genome Research InstituteAmsterdam University Medical CentersInstitut des maladies génétiques ImagineGeorge Mason UniversitySt. Giles FoundationFondation Bettencourt SchuellerNederlandse Organisatie voor Wetenschappelijk OnderzoekNational Institute of Allergy and Infectious DiseasesAgence Nationale de la RechercheGeorgia Clinical and Translational Science AllianceHoward Hughes Medical Institute
- Keywords
- AutoantibodyImmunologyAsymptomaticMedicinePneumoniaAntibodyPhenocopyCoronavirusDiseaseCoronavirus disease 2019 (COVID-19)Internal medicineBiologyInfectious disease (medical specialty)Gene
- Has abstract in OpenAlex
- yes