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Record W3088741547 · doi:10.1016/j.annonc.2020.08.2240

LBA12 PALLAS: A randomized phase III trial of adjuvant palbociclib with endocrine therapy versus endocrine therapy alone for HR+/HER2- early breast cancer

2020· article· en· W3088741547 on OpenAlexfundno aff
Erica L. Mayer, M.I. Gnant, Angela DeMichele, Miguel Martín, Harold J. Burstein, Aleix Prat, Gábor Rubovszky, Kathy D. Miller, Georg Pfeiler, Eric P. Winer, Nicholas Zdenkowski, D. Mark Anderson, Zbigniew Nowecki, Sibylle Loibl, Hannes Fohler, Otto Metzger, Debora Fumagalli, Kathy Puyana Theall, Christian Fesl, Amylou C. Dueck

Bibliographic record

VenueAnnals of Oncology · 2020
Typearticle
Languageen
FieldMedicine
TopicAdvanced Breast Cancer Therapies
Canadian institutionsnot available
FundersChugai PharmaceuticalSamsungGenentechServierAstellas PharmaOncolytics BiotechEisaiGenomic HealthTeva Pharmaceutical IndustriesDaiichi-SankyoPharmaMarCelgeneG1 TherapeuticsBreast Cancer Research FoundationAmgenPfizerAstraZenecaEli Lilly and Company
KeywordsMedicineHazard ratioBreast cancerPalbociclibInternal medicineOncologyAdjuvantCancerInterim analysisRandomized controlled trialConfidence intervalMetastatic breast cancer

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.015
Threshold uncertainty score0.052

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.002
Meta-epidemiology (narrow)0.0030.001
Meta-epidemiology (broad)0.0030.002
Bibliometrics0.0010.001
Science and technology studies0.0010.002
Scholarly communication0.0020.002
Open science0.0020.001
Research integrity0.0020.007
Insufficient payload (model declined to judge)0.0150.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.111
GPT teacher head0.428
Teacher spread0.317 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations29
Published2020
Admission routes1
Has abstractno

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