Consecutive Silver(I) Ion Incorporation into Oligonucleotides containing Cytosine‐Cytosine Mispairs
Why this work is in the frame
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Bibliographic record
Abstract
Abstract Herein, the consecutive incorporation of Ag I ion into the dsDNA containing adjacent C−C mispairs is demonstrated. The melting temperature (T m ) was 8 ° C higher for DNA containing three C−C mispairs upon the addition of three Ag I ions as compared to the Ag I ‐free DNA, and no T m was obtained in the presence of excess Ag I ion, indicating a stable bridging of C‐Ag I −C upon the incorporation of the stoichiometric amount of Ag I per C−C mispair. The circular dichroism (CD) spectra of the dsDNA showed a negative peak at ∼270 nm in the presence of excess Ag I , implying that significant structural changes and a potential aggregation of DNA occurred. Subsequently, the Ag I ‐mediated DNA strands are immobilized on Au surfaces. Their electrochemical properties are monitored using CV, EIS and SECM showing increased overpotentials and charge‐transfer resistances, and decreased the rate constant in the presence of an excess of Ag I , respectively. These results are further supported by the XPS and sulfide‐Au reductive desorption measurements.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it