Consecutive Silver(I) Ion Incorporation into Oligonucleotides containing Cytosine‐Cytosine Mispairs
Bibliographic record
Abstract
Abstract Herein, the consecutive incorporation of AgI ion into the dsDNA containing adjacent C−C mispairs is demonstrated. The melting temperature (Tm) was 8 °C higher for DNA containing three C−C mispairs upon the addition of three AgI ions as compared to the AgI‐free DNA, and no Tm was obtained in the presence of excess AgI ion, indicating a stable bridging of C‐AgI−C upon the incorporation of the stoichiometric amount of AgI per C−C mispair. The circular dichroism (CD) spectra of the dsDNA showed a negative peak at ∼270 nm in the presence of excess AgI, implying that significant structural changes and a potential aggregation of DNA occurred. Subsequently, the AgI‐mediated DNA strands are immobilized on Au surfaces. Their electrochemical properties are monitored using CV, EIS and SECM showing increased overpotentials and charge‐transfer resistances, and decreased the rate constant in the presence of an excess of AgI, respectively. These results are further supported by the XPS and sulfide‐Au reductive desorption measurements.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".