Relationship between Helicobacter pylori infection and recurrent aphthous stomatitis
Bibliographic record
Abstract
Background: Recurrent aphthous stomatitis (RAS) is a very common ulcerative disease that affects about 20% of the population. Helicobacter pylori infection could be involved in the RAS pathogenesis by inducing an oral cytotoxic immunological response to these bacterial antigens. Objective: The objective of this study is to assess the possible relationship of H. pylori infection with RAS. Methods: A search for articles on H. pylori and RAS was performed in the following electronic databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS), and Spanish Medical Index (IME). Ninety-eight articles (29 in PubMed, 69 in WoS, and none in IME) were found between 1997 and 2018, 28 of them duplicates. From 26 articles with full-text availability, three studies with a score below 6 points on the Newcastle–Ottawa scale were excluded. After applying these criteria, 23 studies were included in this review. Statistical Analysis: For dichotomous outcomes, the estimates of effects of an intervention were expressed as odds ratios using Mantel-Haenszel method with 95% confidence intervals. The Pearson's Chi-square test was also used when necessary. Results: RAS patients were 2.16 times more likely to be infected by H. pylori than controls with a very significant statistical relationship (P < 0.01). 42.0% of RAS patients and 33.8% of controls were infected with H. pylori with a statistically significant association (P = 0.001). Nearly 45.9% of patients infected with H. pylori were located in Asia, 34.7% in the Americas, and 33.0% in Europe, with statistically significant differences (P < 0.01). Conclusions: There is a greater detection of H. pylori in RAS patients than in controls without the disease.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".