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Association of SGLT2 Inhibitors With Cardiovascular and Kidney Outcomes in Patients With Type 2 Diabetes

2020· review· en· 1,212 citations· W3092379111 on OpenAlex· 10.1001/jamacardio.2020.4511

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Non-randomized trialObservationalMeta-analysisNot applicable
Classifier consensus
Observational
Teacher imitation scores

Codex

Observational0.251
Other design0.230
Meta-analysis0.208
Not applicable0.032
Meta-epidemiology (broad)0.006
Systematic review0.003
Randomized trial0.002
Metaresearch0.000
Bibliometrics0.000
Open science0.000
Case report0.000
Meta-epidemiology (narrow)0.000
Non-randomized trial0.000
Research integrity0.000
Scholarly communication0.000
Qualitative0.000
Simulation or modelling0.000
Science and technology studies0.000
Bench or experimental0.000
Theoretical or conceptual0.000

Gemma

Not applicable0.891
Observational0.645
Meta-analysis0.016
Systematic review0.005
Non-randomized trial0.003
Randomized trial0.001
Bibliometrics0.000
Metaresearch0.000
Meta-epidemiology (narrow)0.000
Meta-epidemiology (broad)0.000
Case report0.000
Research integrity0.000
Scholarly communication0.000
Open science0.000
Bench or experimental0.000
Science and technology studies0.000
Qualitative0.000
Simulation or modelling0.000
Theoretical or conceptual0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.009
GPT teacher head0.229
Teacher spread
0.221 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

IMPORTANCE

Sodium-glucose cotransporter 2 (SGLT2) inhibitors favorably affect cardiovascular (CV) and kidney outcomes; however, the consistency of outcomes across the class remains uncertain.

OBJECTIVE

To perform meta-analyses that assess the CV and kidney outcomes of all 4 available SGLT2 inhibitors in patients with type 2 diabetes.

DATA SOURCES

A systematic literature search was conducted in PubMed from January 1, 2015, to January 31, 2020.

STUDY SELECTION

One hundred forty-five records were initially identified; 137 were excluded because of stu…

Retrieved from PubMed through NCBI EFetch. Structured section labels are preserved.