Pharmacological Inhibition of PTEN, using BpV (Phen), Promotes Survival of Retinal Ganglion Cells In Vitro and In Vivo
Bibliographic record
Abstract
Previous work has shown that potassium bisperoxo (1,10-phenanthroline) oxovanadate, BpV(Phen), is a potent protein phosphotyrosine phosphatase (PTPase) inhibitor that preferentially blocks the activity of Phosphatase Tensin Homologue Deleted on Chromosome Ten (PTEN).Currently, it remains unknown how pharmacological inhibition of PTEN by bpV(phen) impacts the survival of mammalian RGCs.Thus, the current study investigated the effect of bpV(phen) on RGC survival in vitro and in vivo and the mechanism mediating this outcome following bpV(phen) administration.Collectively, this study revealed that bpV(phen) promoted survival of injured retinal ganglion cells from mature animals (postnatal day 21 (P21) and adult mice) after injury in vitro and in vivo.Interestingly, data also showed bpV(phen) to have an antagonistic effect on healthy RGCs and promote apoptosis.Lastly, preventing Smad3 from being phosphorylated in the transforming growth factor b (TGF-b) pathway did not augment the survival in bpV(phen)-treated RGCs.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".