S0718 Risk of Surgery for Inflammatory Bowel Disease in the Biologic Era
Bibliographic record
Abstract
INTRODUCTION: Crohn's disease (CD) and ulcerative colitis (UC) often require surgery for disease management. A prior meta-analysis reported the risk of surgery for CD was 14.3% (1 year) and 27.7% (5 year), whereas UC was 4.1% (1 year) and 9.9% (5 year). Though, most of this data were published on patients with inflammatory bowel disease (IBD) diagnosed prior to the biologic era. Our aim was to determine the risk of surgery for persons diagnosed with IBD in the post-biologic era. METHODS: Overall, 5,668 newly diagnosed IBD patients (CD: 3050; UC: 2618) were identified using the Alberta population-based health database from 2010 to 2015. The primary outcome was the proportion of IBD surgeries at 1- and 5-years after diagnosis. Comparative analyses were performed by the chi2 test. RESULTS: The risk of surgery at 1- and 5-years after CD diagnosis was 8.7% (95% confidence interval [CI]: 7.8%–9.6%) and 12.5% [95% CI: 9.9%–15.1%], while the 1- and 5-year risks of surgery for UC were lower at 3.8% [95% CI: 2.5%–5.0%] and 6.1% [95% CI: 4.4%–8.0%] (Table 1). The largest proportion of surgeries were performed in the Calgary zone and among persons aged 19–64 years. Comparative analyses did not reveal any significant differences in surgical rates between sex, region, and age. CONCLUSION: For persons diagnosed with IBD in 2010–2015, the risk of surgery appears to be decreasing when compared to historical reports.Table 1
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.001 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.008 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".