Species-specific probiotic Lactobacillus johnsonii CPN23 supplementation modulates blood biochemical profile and erythrocytic antioxidant indices in Labrador dogs
Bibliographic record
Abstract
The present investigation was conducted to study the blood biochemical profile and erythrocytic antioxidant indices in response to a canine-origin probiotic. Labrador adult female dogs (15) were distributed into 3 equal groups. Dogs in control group (CON) received a placebo MRS broth in the homemade basal diet as per the NRC requirements. In other 2 groups, dogs received either canine-origin probiotic (Lactobacillus johnsonii CPN23; cPRO) developed at our laboratory or dairy-origin probiotic (Lactobacillus acidophilus NCDC15; dPRO) in the same basal diet. The experimental duration was 13-weeks. The probiotics supplementation was discontinued after 9-weeks to study the withdrawal effects during the next 4-weeks. Blood was collected at 0, 30, 60 and 90 days of feeding and analyzed for various metabolites and antioxidants. The results indicated that the plasma glucose showed a reduction in both cPRO and dPRO groups vis-a-vis the CON group; however, total protein remained higher in both cPRO and dPRO as compared to CON. The total cholesterol was lower in cPRO and dPRO groups as compared to CON. The HDL/LDL ratio became wider in cPRO and dPRO groups in comparison to the CON. The erythrocytic lipid peroxidation and the levels of antioxidants including reduced glutathione, catalase and glutathione S-transferase remained unaltered by the probiotic use; however, the activity of superoxide dismutase and glutathione peroxidase was higher in cPRO. It is concluded that probiotic supplementation was effective besides having potential to augment the antioxidant status in dogs.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".