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SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020

2020· article· en· W3094422077 on OpenAlexfundno aff
Sheila Lumley, David W. Eyre, Anna McNaughton, Alison Howarth, Sarah Hoosdally, Stephanie B. Hatch, James Kavanagh, Kevin Chau, Louise Downs, Stuart Cox, Laura Dunn, Anita Justice, Susan Wareing, Kate E. Dingle, Justine Rudkin, Kathryn Auckland, Alexander Fyfe, Jai S. Bolton, Robert S. Paton, Alexander J. Mentzer, Katie Jeffery, Monique Andersson, Tim James, Tim Peto, Brian D. Marsden, Gavin Screaton, Richard J. Cornall, Paul Klenerman, Daniel Ebner, David I. Stuart, Derrick W. Crook, Nicole Stoesser, Stephen Kennedy, Craig Thompson, Sunetra Gupta, Philippa C. Matthews

Bibliographic record

VenueEurosurveillance · 2020
Typearticle
Languageen
FieldMedicine
TopicCOVID-19 Impact on Reproduction
Canadian institutionsnot available
FundersUniversity of OxfordMedical Research CouncilKennedy Trust for Rheumatology ResearchEuropean Federation of Pharmaceutical Industries and AssociationsRobertson FoundationNIHR Oxford Biomedical Research CentreWellcome TrustNovartis PharmaOntario Genomics InstituteOxford University Hospitals NHS Foundation TrustMerck KGaANational Institute for Health and Care ResearchFundação de Amparo à Pesquisa do Estado de São PauloGenome CanadaOntario GenomicsPfizer
KeywordsSeroprevalenceMedicinePregnancyEpidemiologyCohortSeroconversionImmunologyPopulationCohort studySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ObstetricsAntibodyVirologyCoronavirus disease 2019 (COVID-19)SerologyInternal medicineEnvironmental healthBiologyDiseaseInfectious disease (medical specialty)

Abstract

fetched live from OpenAlex

SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson's correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.075
Threshold uncertainty score0.149

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.061
GPT teacher head0.364
Teacher spread0.303 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations20
Published2020
Admission routes1
Has abstractyes

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