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SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020

2020· article· en· W3094422077 on OpenAlex
Sheila Lumley, David W. Eyre, Anna McNaughton, Alison Howarth, Sarah Hoosdally, Stephanie B. Hatch, James Kavanagh, Kevin Chau, Louise Downs, Stuart Cox, Laura Dunn, Anita Justice, Susan Wareing, Kate E. Dingle, Justine Rudkin, Kathryn Auckland, Alexander Fyfe, Jai S. Bolton, Robert S. Paton, Alexander J. Mentzer, Katie Jeffery, Monique Andersson, Tim James, Tim Peto, Brian D. Marsden, Gavin Screaton, Richard J. Cornall, Paul Klenerman, Daniel Ebner, David I. Stuart, Derrick W. Crook, Nicole Stoesser, Stephen Kennedy, Craig Thompson, Sunetra Gupta, Philippa C. Matthews

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

fundA Canadian funder is recorded on the work.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueEurosurveillance · 2020
Typearticle
Languageen
FieldMedicine
TopicCOVID-19 Impact on Reproduction
Canadian institutionsnot available
FundersUniversity of OxfordMedical Research CouncilKennedy Trust for Rheumatology ResearchEuropean Federation of Pharmaceutical Industries and AssociationsRobertson FoundationNIHR Oxford Biomedical Research CentreWellcome TrustNovartis PharmaOntario Genomics InstituteOxford University Hospitals NHS Foundation TrustMerck KGaANational Institute for Health and Care ResearchFundação de Amparo à Pesquisa do Estado de São PauloGenome CanadaOntario GenomicsPfizer
KeywordsSeroprevalenceMedicinePregnancyEpidemiologyCohortSeroconversionImmunologyPopulationCohort studySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ObstetricsAntibodyVirologyCoronavirus disease 2019 (COVID-19)SerologyInternal medicineEnvironmental healthBiologyDiseaseInfectious disease (medical specialty)

Abstract

fetched live from OpenAlex

SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson's correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.444
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.061
GPT teacher head0.364
Teacher spread0.303 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it