Comparison Of Dexmedetomidine and Morphine For Postoperative Pain and Sedation Management in Pediatric Patients Undergoing Congenital Cardiac Surgery: A Retrospective Study
Bibliographic record
Abstract
Objective: In this retrospective study, it was aimed to compare the effects of dexmedetomidine and morphine on postoperative pain, sedation, extubation time and hemodynamics in patients who underwent congenital cardiac surgery. Material and Methods: From December 2012 to December 2013, 46 patients between 1 to 5 years of age, who underwent congenital cardiac surgery were included and divided into two groups based on the sedative regimen used in the postoperative period. Twenty-three patients (Group Morp) received morphine at an infusion dose of 0.01 to 0.04 mg/kg/h; 23 patients (Group Dex) received dexmedetomidine at an infusion dose of 0.05 to 0.5 mcg/kg/h. Pain scores were measured using Children's Hospital Eastern Ontario Pain Scale (CHEOPS); sedation scores with the Ramsay Sedation Scale (RSS); and hemodynamic parameters were recorded with these measured values. Sedation debth was monitored by using the Bispectral Index (BIS). In this retrospective study, postoperative pain, sedation and hemodynamic effects of intravenous dexmedetomidine in pediatric patients undergoing congenital cardiac surgery, and the effects of mechanical ventilation duration and length of intensive care unit (ICU) stay were compared with morphine. Results: Mean doses of morphine and dexmedetomidine infused were 7.04±3.94 mg/24 h and 94.33±48.38 mcg/24 h, respectively. BIS values were higher in Group Dex than Group Morp (p<0.01). Mechanical ventilation duration was shorter in Group Dex compared to Group Morp 5.74±1.98 hours vs 7.83±3.08 hours) (p<0.05). The length of ICU stay and other outcome measurements between the two groups were similar. Heart rate was lower in the group Dex only in the first two hours (p<0.01). CHEOPS pain scores were similar in two groups (p> 0.05). RSS scores at 1st, 2nd, 3rd, 4th hours were higher in Group Dex than Group Morp (p <0.01); however, there was no difference between the groups in terms of RSS scores at the 12th, 16th, 20th and 24th hours (p> 0.05). There was no difference between the groups in terms of the frequency of side effects (p> 0.05). Conclusion: With regard to our study findings, dexmedetomidine can provide effective analgesia and sedation with shorter mechanical ventilation duration without adverse reaction compared to morphine in pediatric patients undergoing congenital cardiac surgery.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".