Commentary: Coronavirus disease 2019 and acute aortic dissection: So many questions, so few answers
Bibliographic record
Abstract
Central MessageCOVID-19 has complicated patient care in acute aortic dissection, requiring a thoughtful team approach that is individualized for each patient.See Article page 50. COVID-19 has complicated patient care in acute aortic dissection, requiring a thoughtful team approach that is individualized for each patient. See Article page 50. The coronavirus disease 2019 (COVID-19) pandemic has challenged our ability to deliver safe, timely, and high-quality care for our patients with acute aortic dissection while protecting our highly specialized aortic team members. The pandemic has influenced the clinical, educational, and administrative activities of cardiac surgery units globally. Furthermore, our ability to effectively treat patients has been severely affected. This has translated into a dramatic reduction in elective aneurysm repairs and increased wait times with consequent potential harm to patients. The pandemic has also affected urgent surgical care: We suspect that patients have avoided seeking hospital care due to fear of acquiring COVID-19, resulting in reduced demand for emergency dissection repair. This is corroborated by an increase in the number of patients dying out of hospital, and an overall excess mortality seen in several jurisdictions during the pandemic not directly attributable to COVID-19 infections.1El-Hamamsy I. Brinster D.R. DeRose J.J. Girardi L.N. Hisamoto K. Imam M.N. et al.The COVID-19 pandemic and acute aortic dissections in New York: a matter of public health.J Am Coll Cardiol. 2020; 76: 227-229Crossref PubMed Scopus (43) Google Scholar Murana and colleagues2Murana G. Folesani G. Botta L. Di Marco L. Leone A. Loforte A. et al.The effect of the coronavirus disease 2019 lockdown on type A acute aortic dissection: insights from Bologna.J Thorac Cardiovasc Surg Tech. 2020; 4: 50-54Scopus (3) Google Scholar from Bologna share their heroic experience with managing patients with acute aortic dissection early during the first wave of the pandemic through a national lockdown. They report patient avoidance behaviors causing delays in diagnosis, late presentations with malperfusion, and several patients who died before undergoing definitive repair. They were fortunate to have rapid testing protocols to confirm COVID-19 negative status on all patients undergoing operations who ultimately had very good outcomes with surgical repair. Although the authors observed pulmonary infiltrates on preoperative computed tomography scans that were concerning for COVID-19 in 30% of their patients, none of them tested positive for COVID-19. Patients with acute aortic dissection will remain a challenging group to treat during this ongoing pandemic. Timely access to emergency surgical care remains a life-saving priority; however, several considerations need to be made.•Rapid point-of-care COVID-19 testing should be systematically implemented to guide decision making for emergency operations and protect the surgical team and determine personal protective equipment requirements. COVID–19-positive patients undergoing cardiovascular surgery have an extremely high risk for perioperative death3COVIDSurg CollaborativeMortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study.Lancet. 2020; 396: 27-38Abstract Full Text Full Text PDF PubMed Scopus (1237) Google Scholar and anecdotal reports of acute dissection repair suggest similarly poor outcomes.•When taking a COVID–19-positive or suspect patient to the operating room for acute type A aortic dissection repair, operative expedience is likely paramount. Strategies to simplify surgical repair and minimize circulatory arrest and myocardial ischemic times should be considered. In this scenario, the primary focus must be on perioperative survival, even at the cost of late reoperation.•Lastly, if patients are COVID–19-positive, it would be wise to discuss the likelihood for postoperative respiratory failure and the potential need for aggressive respiratory support, including prolonged mechanical ventilation, tracheostomy, proning, and extracorporeal membrane oxygenation. Palliation may be considered in patients who are COVID-19 positive with extremely high-risk features (eg, octogenarians and patients with malperfusion syndrome) or hemodynamic instability. Patients with acute aortic dissection remain challenging at the best of times. COVID-19 has complicated patient care significantly, requiring a very careful and thoughtful team approach that is individualized for each patient, considering local pandemic activity and resources. These patients deserve our very best efforts, while balancing the needs of the pandemic as a whole. The effect of the coronavirus disease 2019 lockdown on type A acute aortic dissection: Insights from BolognaJTCVS TechniquesVol. 4PreviewItaly was among the first countries dealing with the spread of the coronavirus disease 2019 (COVID-19) pandemic, with more than 200,000 positive cases and about 27,000 deaths at the end of April 2020.1 According to the rapid surge in the number of cases, the Italian government imposed, from March 9 to May 4, 2020, specific mobility restrictions (ie, lockdown). Full-Text PDF Open Access
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".