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Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry
Marc Humbert, David Pittrow, Gérald Simonneau, Henning Gall, Ekkehard Grünig, Hans Klose, Michael Halank, David Langleben, Repke J. Snijder, Pilar Escribano Subías, Lisa Mielniczuk, Tobias Lange, Jean‐Luc Vachiéry, Hubert Wirtz, Douglas Helmersen, Iraklis Tsangaris, Joan Albert Barberà, Joanna Pepke‐Żaba, Anco Boonstra, Stephan Rosenkranz, Silvia Ulrich, Regina Steringer‐Mascherbauer, Marion Delcroix, Pavel Jansa, Iveta Šimková, George Giannakoulas, Jens Klotsche, Christian Meier, Marius M. Hoeper, Jorge Cáneva, Graciela Tuhay, Mirta Díez, María L. Talavera, Adriana Acosta, Norberto Vulcano, Martín Bosio, Lorena Maldonado, Sabino Deleo, Luciano Melatini, Anne Keogh, Eugene Kotlyar, John Feenstra, Nathan Dwyer, Heath Adams, Wendy Stevens, Peter Steele, Susanna Proudman, Robert Minson, Glenn Reeves, Melanie Lavender, Benjamin Ng, Michele Mackenzie, Lisa C. Barry, Margarethe Gruenberger, Charlotte Huber, Iréne Lang, Ioana Tilea, Roela Sadushi‐Kolici, Judith Löffler‐Ragg, Lisa-Theresa Feistmantl, P Evrard, Renaud Louis, Julien Guiot, Marco Naldi, Michel De Pauw, Sanjay Mehta, Rafael Conde Camacho, Patricia Parada Tovar, Alejandro Londoño, Felipe Campo, P Awamleh Garcia, Camila Lema, Mauricio Orozco‐Levi, William Martínez, Jens Erik Nielsen‐Kudsk, Søren Mellemkjær, Ly Anton, Alan Altraja, Tapani Vihinen, Tuija Vasankari, Olivier Sitbon, Vincent Cottin, L. Têtu, Elise Noël‐Savina, Nicole Shearman, Susanne Tayler, Ilona Olzik, Christine Kulka, Jan Grimminger, Marcel Simon, Anna Nolde, Tim Oqueka, Lars Harbaum, Benjamin Egenlauf, Ralf Ewert, Christian Schulz, Sabine Regotta, Tilmann Kramer, Susanne Knoop-Busch, Felix Gerhardt, Stavros Konstantinides, Georgia Pitsiou, Ioannis Stanopoulos, Evdokia Sourla, S. A. Mouratoglou, Haralambos Karvounis, Athanasios Pappas, Dimitrios Georgopoulos, Michail Fanaridis, Ioanna Mitrouska, Lampros K. Michalis, Κωνσταντίνος Παππάς, Anna Kotsia, Seán Gaine, Carmine Dario Vizza, Giovanna Manzi, Roberto Poscia, Roberto Badagliacca, Piergiuseppe Agostoni, Noemi Bruno, Stefania Farina, Michele D’Alto, Paola Argiento, Anna Correra, Giovanni Maria Di Marco, Chiara Cresci, Vieri Vannucchi, Elena Torricelli, Alessio Garcea, Alberto Pesci, Luca Sardella, Giuseppe Paciocco, Federico Pane, Andrea Maria D’Armini, Maurizio Pin, Valentina Grazioli, Giulia Massola, Antonio Sciortino, Renato Prediletto, Carolina Bauleo, Edoardo Airò, Rudina Ndreu, Ivana Pavlickova, Claudio Lunardi, Massimiliano Mulè, Silvia Farruggio, Serena Costa, Giuseppe Galgano, Mario Petruzzi, Anna De Luca, Francesco Lombardi, Loris Roncon, Luca Conte, Claudio Picariello, Gil Wirtz, Myriam Alexandre, Anton Vonk Noordegraaf, H. Boogaard, Johannes J. Mager, Herre J. Reesink, Leon M. van den Toorn, Karin A. Boomars, Graça Castro, Gonçalves Tania, Rui Baptista, António Marinho, Teresa Shiang, Ana de Oliveira, Daniel Coutinho, Joana Sousa, María José Loureiro, Débora Repolho, Susana Jesus, Marta Capinha, João Agostinho, Tânia Aparecida Marchiori Oliveira Cardoso, Andréia Silva da Rocha, Mafalda Espinha, K. I. Ivanov, Dalyana Eduardovna Alexeeva, Marina Vadimovna Batalina, D. Hegya, T. N. Zvereva, С. Н. Авдеев, Н. А. Царева, Albert Sarvatovich Galyavich, Bykov Aleksander Nikolaevich, Е В Филиппов, Olga Eduardovna Yakovleva, Olga Borisovna Pavlova, Elena Skripkina, T. V. Martynyuk, Irina Fedorovna Bukatova, Anna Viktorovna Tregubova, Dmitry Yurievich Platonov, Tatyana Mikhaylovna Kolomeytseva, Abdullah Al Dalaan, A A Abd-Elsayed, Ihab Weheba, Sarferaz Saleemi, Hussam Sakkijha, Marcela Boháčeková, Tatiana Valkovičová, Iveta Farkasova, Carlos Andrés Quezada, Lucilla Piccari, Isabel Blanco, Laura Sebastián, Antonio Román, Manuel López, Remedios Otero, Teresa Elías-Hernández, Isabel Asencio, Josefa Jiménez Arjona, Raúl Menor Almagro, Salvador López-Cárdenas, Salvador Alcaraz García, Patricia Villanueva Rodríguez, Raquel López, Alberto E. García, Francisco Fernández‐Avilés, Sebastian De La Pava, Raquel Yotti, Gregorio Pérez Peñate, Fernando León Marrero, José M. Cifrián, Amaya Martínez Meñaca, Lecue Pilar Alonso, Sonia Fernández Rozas, David Iturbe‐Fernández, V.M. Mora Cuesta, Stefan Söderberg, S. Bartfay, Bengt Rundqvist, Monthir Alfetlawi, Peter Wodlin, Esther I. Schwarz, Rudolf Speich, Frédéric Lador, Thierry Rochat, Paola Gasche‐Soccal, Chih‐Hsin Hsu, Tsung‐Hsien Lin, Ho‐Ming Su, Wen‐Ter Lai, Chun Yuan Chu, Po‐Chao Hsu, Wen‐Chol Voon, Hsueh‐Wei Yen, Jacob Yih-Jer Wu, Shu‐Hao Wu, Wen-Pin Huang, Man-Cai Fong, Chien-Lung Huang, Ping‐Hung Kuo, Yen‐Hung Lin, Jiunn‐Lee Lin, Chi‐Sheng Hung, Cho‐Kai Wu, Shih‐Hsien Sung, Wei‐Chun Huang, Chin-Chang Cheng, Shu‐Hung Kuo, Wen-Hwa Wang, Wan‐Jing Ho, Tsu‐Shiu Hsu, Bülent Mutlu, Gül Öngen, Zeynep Un, Gülfer Okumuş, İsmail Hanta, Paul A. Corris, Andrew J. Peacock, Colin Church, Mark Toshner, Michael Newnham
Bibliographic record
VenueRespiratory Medicine · 2020
Typearticle
Languageen
FieldMedicine
TopicPulmonary Hypertension Research and Treatments
Canadian institutionsLawson Health Research InstituteMcGill UniversityUniversity of CalgaryJewish General HospitalUniversity of OttawaAlberta Health Services
FundersCilagActelion PharmaceuticalsMerck Sharp and DohmeAOP OrphanBayerBiogenSanofiMerckAcceleronUnited Therapeutics CorporationEli Lilly and CompanyAstraZenecaPfizer
KeywordsRiociguatMedicinePulmonary hypertensionAdverse effectChronic thromboembolic pulmonary hypertensionPneumoniaInternal medicineCardiologyHeart failure
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.128
Threshold uncertainty score0.821
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.132
GPT teacher head0.326
Teacher spread0.194 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations35
Published2020
Admission routes1
Has abstractno