Predictive Value of Inflammatory Mediators and Effectors in Coronary Atherosclerosis - Its Link with Adverse Outcomes of Percutaneous Coronary Intervention
Bibliographic record
Abstract
Introduction. Progress of interventional cardiology causes decrease of CHD complications, but new problems such as late thrombosis and stent restenosis, as well as neoarterogenesis were come in sight. According the literature data, stent thrombosis after percutaneous coronary intervention (PCI) developed in 0,5-1,5% of cases, restenosis if stent due neointimal hyperplasia a – in 2-10%, frequency of recurrent coronary interventions – 6-23%, that depends on type of stent (drug eluting stents with everolimus or bare metalic stents). The “latecatchup” fenomen caused weak and long inflammation, that can cause this complications. Aim of research was to study the level of inflammatory effectors and mediators in 164 patients with coronary atherosclerosis and to establish their prognostic value in major adverse coronary events (MACE) development in the long-term period after the percutaneous coronary intervention (PCI). Material and methods. The study included 164 patients with coronary atherosclerosis (CA), who were treated at the State Institution “Republican Specialized Scientific Practical Medical Centre of Surgery named after academician V. Vakhidov” in the period from 2012-2017. All patients had CHD, stable angina of functional class 3 (FC-III) according to the classification of The Canadian Cardiovascular Society (CCS). ROC – analysis was performed and area under curve were evaluated for CRP, VEGF, TNF-a, IL-6. Results. According to the results of ROC-analysis, the following markers have a predictive value in determining the risk of MACE 12 months after the PCI: baseline level of VEGF, IL-6; the threshold level for predicting an unfavorable long-term PCI result for IL -6 - is more than 17 pg/ml; for VEGF - more than 98.5 pg/ml. An increase in the concentration of CRP from 1 to 5 days after PCI, as well as a consistently high level of IL-6 and TNF-a within 5 days after PCI are associated with a high risk of MACE; high quality test found for CRP delta between 1 and 5 days after PCI (AUC=0.809 (95% CI: 0.686 to 0.899), with 71% sensitivity, 98% specificity.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".