Photoencapsulated-Mesenchymal Stromal Cells in Biodegradable Thiol-Acrylate Hydrogels Enhance Regeneration of Craniofacial Bone Tissue Defects
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Post-publication record
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Abstract
Aim: This study investigated biodegradable thiol-acrylate hydrogels as stem cell carriers to facilitate cranial bone regeneration. Materials & methods: Two formulations of thiol-acrylate hydrogels (5 and 15 wt% Poly[ethylene glycol]-diacrylate [PEGDA] hydrogels) were used as stem cell carriers. Bone marrow mesenchymal stromal cells and dental pulp mesenchymal stromal cells were photoencapsulated and cultured in basal or osteogenic medium 3 days before the surgery. Using New Zealand White Rabbits, four defects (5 mm diameter and 2 mm thickness) were created and hydrogel scaffolds were implanted in each rabbit cranium for 6 weeks. Results & Conclusion: AlamarBlue assay showed increasing metabolic activity levels in 5 wt% PEGDA hydrogels than 15 wt% PEGDA hydrogels. Photoencapsulated-mesenchymal stromal cells in 15 wt% PEGDA hydrogels demonstrated significantly increasing alkaline phosphatase activity levels on day 7 compared with days 1 and 3. Histological diagnosis showed 5 wt% PEGDA hydrogels resulted in lower averaged residual gel areas than 15 wt% PEGDA hydrogel specimens and control groups 6 weeks postimplantation.
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The record
- Venue
- Regenerative Medicine
- Topic
- Bone Tissue Engineering Materials
- Field
- Engineering
- Canadian institutions
- —
- Funders
- Canadian Bureau for International Education
- Keywords
- Regeneration (biology)Self-healing hydrogelsStromal cellMesenchymal stem cellCraniofacialAcrylateCell biologyChemistryMedicinePolymer chemistryPathologyBiologyCopolymerPolymerOrganic chemistry
- Has abstract in OpenAlex
- yes