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Record W3107434291 · doi:10.1093/jas/skaa278.334

400 Functional amino acids to improve pig robustness

2020· article· en· W3107434291 on OpenAlexaff
Daniel A Columbus

Bibliographic record

VenueJournal of Animal Science · 2020
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicAnimal Nutrition and Physiology
Canadian institutionsGenome Prairie
Fundersnot available
KeywordsImmune systemBiologyAmino acidIntestinal permeabilityMetabolismBiochemistryImmunology

Abstract

fetched live from OpenAlex

Abstract Pigs are continuously exposed to pathogens and immune-stimulatory antigens that negatively impact animal productivity. In general, this decrease in productivity is the result of reduced feed intake and increased demand for nutrients to mount an immune response. In addition, immune system stimulation alters amino acid metabolism and utilization, with amino acids redirected from growth towards supporting the immune response. A number of previous studies have shown that nutrient requirements for some amino acids, such as methionine, tryptophan, and threonine, are higher in immune-challenged vs. healthy animals, and supplementation with these “functional” amino acids may improve performance and the immune response. In addition to effects on whole-body growth, both dietary composition and immune challenge result in significant physiological alterations to the gastrointestinal tract, including changes in gut motility, permeability, digestive enzyme secretion, absorptive capacity, and mucin production. Alterations to the gut epithelium induced by dietary protein and/or fiber content may lead to increased susceptibility to pathogens and immune stimulation. Functional amino acids have been shown to be important in the maintenance of gut barrier function as well as immune response. An increased understanding of the interaction of nutrition and the pig’s immune response will be a key component in efforts to reduce feed costs and antibiotic use while improving animal robustness and profitability of the swine industry.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.015

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0050.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.040
GPT teacher head0.242
Teacher spread0.202 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2020
Admission routes1
Has abstractyes

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