PSVI-33 Undenatured type II collagen mitigates inflammation and cartilage degeneration in healthy untrained Labrador retrievers after exercise
Bibliographic record
Abstract
Abstract Exercise can cause microtrauma in the tissue and joints of dogs, resulting in a cycle of inflammation and discomfort even in healthy dogs. The aim of this trial was to evaluate the effect of undenatured type II collagen supplemented on inflammation and cartilage degeneration after exercise in untrained, healthy dogs. In this experiment, 40 healthy Labrador retrievers (20m/20f; Range-5-12yrs; Avg-8yrs) were sorted into two groups: undenatured type II collagen group receiving 40mg UC-II® (10mg Collagen Type II/Min. 3% Undenatured Type II Collagen; Lonza Consumer Health, Inc.) and placebo (P) group receiving 40mg maltodextrin daily by capsule. After 2wks supplement loading, all dogs performed a 4.66 ± 0.34km endurance run. Blood was collected at baseline, 1h pre-run, and 24h post-run for hematology/biomarkers including interleukin-6 (IL-6) as an inflammatory marker and cartilage oligomeric matrix protein (COMP) as a cartilage degeneration marker. Undenatured type II collagen supplemented dogs had significantly lower IL-6 vs P at post-run (p< 0.01), as well as significant decreases from pre to post-run (P = 0.03), vs P with no significant change (P = 0.16). COMP was significantly lower in undenatured type II collagen supplemented dogs at 24h post-run compared to pre-run (P = 0.02), with P dogs having no significant differences between timepoints (P = 0.24). At both 1h pre- and 24h post-run undenatured type II collagen supplemented dogs had no significant increases in neutrophil:lymphocyte ratio (NLR; inflammatory marker), but P dogs had significantly higher NLR compared to baseline (P = 0.01). NLR was also significantly lower in undenatured type II collagen supplemented dogs compared to P dogs at pre-run (P < 0.01). Undenatured type II collagen supplemented dogs showed significantly lower white blood cell counts after supplementation compared to P dogs (P < 0.05) (Table 1). In summary, untrained Labrador retrievers supplemented with undenatured type II collagen had decreased inflammation and cartilage degeneration compared to non-supplemented dogs after exercise.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".