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Record W3109761717 · doi:10.1016/s2213-2600(20)30471-9

Clinical trials in critical care: can a Bayesian approach enhance clinical and scientific decision making?

2020· review· en· W3109761717 on OpenAlexafffund
Christopher J. Yarnell, Darryl Abrams, Matthew R. Baldwin, Daniel Brodie, Eddy Fan, Niall D. Ferguson, May Hua, Purnema Madahar, Laveena Munshi, Gavin D. Perkins, Gordon D. Rubenfeld, Arthur S. Slutsky, Hannah Wunsch, Robert Fowler, George Tomlinson, Jeremy R. Beitler, Ewan C. Goligher

Bibliographic record

VenueThe Lancet Respiratory Medicine · 2020
Typereview
Languageen
FieldMedicine
TopicSepsis Diagnosis and Treatment
Canadian institutionsInstitute for Clinical Evaluative SciencesToronto General HospitalUniversity of TorontoUniversity Health NetworkSunnybrook Health Science CentreSinai Health SystemToronto Rehabilitation InstituteHealth Sciences CentreMount Sinai Hospital
FundersNational Heart, Lung, and Blood InstituteNational Institute on AgingInnovate UKMedical Research CouncilCanadian Institutes of Health ResearchAmerican Federation for Aging ResearchNational Institute for Health and Care ResearchDepartment of Health and Social CareWellcome TrustNational Institutes of Health
KeywordsFrequentist inferenceBayesian probabilityMedicineClinical trialFrequentist probabilityHarmBayesian statisticsBayes' theoremSkepticismBayesian inferenceIntensive care medicineComputer scienceArtificial intelligencePsychologyEpistemologyPathology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.028
metaresearch head score (Gemma)0.046
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.965
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0280.046
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0110.001
Bibliometrics0.0000.001
Science and technology studies0.0000.002
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.659
GPT teacher head0.625
Teacher spread0.033 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations116
Published2020
Admission routes2
Has abstractno

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