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Record W3110323992 · doi:10.1038/s41586-020-2961-x

Multiple wheat genomes reveal global variation in modern breeding

2020· article· en· W3110323992 on OpenAlexafffund
Sean Walkowiak, Liangliang Gao, Cécile Monat, Georg Haberer, Mulualem T. Kassa, Jemima Brinton, Ricardo H. Ramírez-González, Markus C. Kolodziej, Emily Delorean, Dinushika Thambugala, Valentyna Klymiuk, Brook Byrns, Heidrun Gundlach, Venkat Bandi, Jorge Núñez Siri, Kirby T. Nilsen, Catharine Aquino, Axel Himmelbach, Dario Copetti, Tomohiro Ban, Luca Venturini, Michael Bevan, Bernardo Clavijo, Dal-Hoe Koo, Jennifer Ens, Krystalee Wiebe, Amidou N’Diaye, Allen K. Fritz, Carl Gutwin, Anne Fiebig, Nigel Fosker, Bin Xiao Fu, Gonzalo Garcia Accinelli, Keith A. Gardner, Nick Fradgley, Juan J. Gutiérrez-González, Gwyneth Halstead-Nussloch, Masaomi Hatakeyama, ChuShin Koh, Jasline Deek, Alejandro C. Costamagna, Pierre R. Fobert, Darren Heavens, Hiroyuki Kanamori, Kanako Kawaura, Fuminori Kobayashi, Ksenia V. Krasileva, Tony Kuo, Neil McKenzie, Kazuki Murata, Yusuke Nabeka, Timothy Paape, Sudharsan Padmarasu, Lawrence Percival‐Alwyn, Sateesh Kagale, Uwe Scholz, Jun Sese, Philomin Juliana, Ravi P. Singh, Rie Shimizu‐Inatsugi, David Swarbreck, James Cockram, Hikmet Budak, Toshiaki Tameshige, Tsuyoshi Tanaka, Hiroyuki Tsuji, Jonathan Wright, Burkhard Steuernagel, Ian Small, Sylvie Cloutier, Gabriel Keeble‐Gagnère, Gary J. Muehlbauer, Josquin Tibbets, Shuhei Nasuda, Joanna Melonek, Pierre Hucl, Andrew Sharpe, Matthew D. Clark, Erik Legg, Arvind K. Bharti, Peter Langridge, Anthony Hall, Cristóbal Uauy, Martin Mascher, Simon G. Krattinger, Hirokazu Handa, Kentaro K. Shimizu, Assaf Distelfeld, K. J. Chalmers, Beat Keller, Klaus Mayer, Jesse Poland, Nils Stein, Curt A. McCartney, M. Spannagl, Thomas Wicker, Curtis Pozniak

Bibliographic record

VenueNature · 2020
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicWheat and Barley Genetics and Pathology
Canadian institutionsUniversity of ManitobaUniversity of GuelphAgriculture and Agri-Food CanadaNational Research Council CanadaGlobal Institute for Water SecuritySaskatchewan Research Council (Canada)University of Saskatchewan
FundersCore Research for Evolutional Science and TechnologyDirectorate for Biological SciencesJapan Society for the Promotion of ScienceBiotechnology and Biological Sciences Research CouncilAlberta Wheat CommissionEidgenössische Technische Hochschule ZürichBundesministerium für Ernährung und LandwirtschaftGerman Network for Bioinformatics InfrastructureKing Abdullah University of Science and TechnologyNational Agriculture and Food Research OrganizationUniversität ZürichBundesministerium für Bildung und ForschungMinistry of Education, Culture, Sports, Science and TechnologyAustralian GovernmentKansas Wheat CommissionJapan Agency for Medical Research and DevelopmentWestern Grains Research FoundationSaskatchewan Wheat Development CommissionGenome PrairieSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungGrains Research and Development CorporationAgroscopeGenome CanadaNational Science Foundation
KeywordsGenomeBiologyStructural variationGenomicsPlant disease resistancePlant geneticsGeneGeneticsComparative genomicsBiotechnologyPlant breedingComputational biologyEvolutionary biologyAgronomy

Abstract

fetched live from OpenAlex

Abstract Advances in genomics have expedited the improvement of several agriculturally important crops but similar efforts in wheat ( Triticum spp.) have been more challenging. This is largely owing to the size and complexity of the wheat genome 1 , and the lack of genome-assembly data for multiple wheat lines 2,3 . Here we generated ten chromosome pseudomolecule and five scaffold assemblies of hexaploid wheat to explore the genomic diversity among wheat lines from global breeding programs. Comparative analysis revealed extensive structural rearrangements, introgressions from wild relatives and differences in gene content resulting from complex breeding histories aimed at improving adaptation to diverse environments, grain yield and quality, and resistance to stresses 4,5 . We provide examples outlining the utility of these genomes, including a detailed multi-genome-derived nucleotide-binding leucine-rich repeat protein repertoire involved in disease resistance and the characterization of Sm1 6 , a gene associated with insect resistance. These genome assemblies will provide a basis for functional gene discovery and breeding to deliver the next generation of modern wheat cultivars.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.226
Teacher spread0.207 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1,013
Published2020
Admission routes2
Has abstractyes

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