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Record W3111067988 · doi:10.1016/s2215-0366(20)30516-2

Reconceptualising treatment-resistant depression as difficult-to-treat depression

2020· article· en· W3111067988 on OpenAlexafffund
R. Hamish McAllister‐Williams, Celso Arango, Pierre Blier, Koen Demyttenaere, Peter Falkai, Philip Gorwood, Malcolm Hopwood, Afzal Javed, Siegfried Kasper, Jair C. Soares, Eduard Vieta, Allan H. Young, Ανδρέας Παπαδόπουλος, A. John Rush

Bibliographic record

VenueThe Lancet Psychiatry · 2020
Typearticle
Languageen
FieldMedicine
TopicTreatment of Major Depression
Canadian institutionsRoyal Ottawa Mental Health CentreUniversity of Ottawa
FundersNational Institute of Mental HealthNational Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyJanssen BiotechMedical Research CouncilJohnson and JohnsonWellcome TrustRamsay Health CareWestern Economic Diversification CanadaH. Lundbeck A/SServierOtsuka PharmaceuticalAustralian Rotary HealthPfizer UKEuropean College of NeuropsychopharmacologyKing's College LondonBritish Medical AssociationBritish Association for PsychopharmacologyRoyal College of PhysiciansNational Institute for Health and Care ResearchNSW HealthStanley Medical Research InstituteMichael Smith Health Research BCSage TherapeuticsCanadian Institutes of Health ResearchCilagBrain and Behavior Research FoundationNational Health and Medical Research CouncilAstraZenecaAmerican Foundation for Suicide Prevention
KeywordsDepression (economics)Treatment-resistant depressionMedicineMEDLINEPsychiatryPsychologyBiologyMajor depressive disorderMood

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.110
Threshold uncertainty score0.924

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.046
GPT teacher head0.314
Teacher spread0.269 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations30
Published2020
Admission routes2
Has abstractno

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